A novel multilocus genotyping assay to identify genetic predictors of stroke in sickle cell anaemia

被引：22

作者：

Hoppe, C

Cheng, S

Grow, M

Silbergleit, A

Klitz, W

Trachtenberg, E

Erlich, H

Vichinsky, E

Styles, L

机构：

[1] Childrens Hosp Oakland, Dept Hematol Oncol, Oakland, CA 94609 USA

[2] Roche Mol Syst, Alameda, CA USA

[3] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA

[4] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 114卷 / 03期

关键词：

sickle cell anaemia; stroke; genetic predictors; polymorphisms; candidate genes;

D O I：

10.1046/j.1365-2141.2001.02997.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a novel multilocus genotyping assay permitting simultaneous identification of 60 candidate markers for stroke in sickle cell anaemia (SCA). Based on cerebral magnetic resonance imaging (MRI), 69 patients were divided into stroke and control groups. The variant allele, CBS 278thr, showed protection from stroke, whereas the apoE3 allele showed a trend towards association with increased stroke risk. Several other variant alleles [TNF alpha (-308)A, CETP (-628)A, apoCIII (-641)A] showed a trend towards significant associations with stroke risk. These preliminary results on a small group of patients suggest that a multilocus genotyping assay may be valuable in identifying genes that increase the risk of stroke in SCA.

引用

页码：718 / 720

页数：3

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