Trichothiazole A, a dichlorinated polyketide containing an embedded thiazole isolated from Trichodesmium blooms

被引：10

作者：

Belisle, Richard S. ^{[1
]}

Via, Christopher W. ^{[1
]}

Schock, Tracey B. ^{[2
]}

Villareal, Tracy A. ^{[3
]}

Zimba, Paul V. ^{[4
,5
]}

Beauchesne, Kevin R. ^{[6
]}

Moeller, Peter D. R. ^{[6
]}

Bertin, Matthew J. ^{[1
]}

机构：

[1] Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Coll Pharm, 7 Greenhouse Rd, Kingston, RI 02881 USA

[2] NIST, Hollings Marine Lab, 331 Ft Johnson Rd, Charleston, SC 29412 USA

[3] Univ Texas Austin, Marine Sci Inst, 750 Channel View Dr, Port Aransas, TX 78373 USA

[4] Texas A&M, Ctr Coastal Studies, 6300 Ocean Dr, Corpus Christi, TX 78412 USA

[5] Texas A&M, Dept Life Sci, 6300 Ocean Dr, Corpus Christi, TX 78412 USA

[6] Natl Ocean Serv, Emerging Toxins Program, NOAA, Hollings Marine Lab, 331 Ft Johnson Rd, Charleston, SC 29412 USA

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 43期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Trichodesmium; Thiazole; Heterocycles; CYANOBACTERIUM LYNGBYA-MAJUSCULA; NATURAL-PRODUCT; CURACIN-A; BIOSYNTHESIS; HETEROCYCLES; METABOLITE;

D O I：

10.1016/j.tetlet.2017.09.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mass spectrometry-guided isolation of the lipophilic extract of Trichodesmium bloom material led to the isolation and structure characterization of a new thiazole-containing di-chlorinated polyketide (1). The structure of 1 was deduced using 1D and 2D NMR analysis, high-resolution mass spectrometry analysis and complementary spectroscopic procedures. Trichothiazole A possesses interesting structural features, such as a terminal alkyne, two vinyl chlorides and a 2,4-disubstituted thiazole. Trichothiazole A showed moderate cytotoxicity to Neuro-2 A cells (EC50: 13.3 +/- 1.1 mu M). (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：4066 / 4068

页数：3

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