Increased Basal Blood Histamine Levels in Patients with Self-Reported Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs

被引:3
作者
Kakolyri, Maria [1 ]
Strikou, Flora [1 ]
Kavallari, Andriana [1 ]
Chliva, Caterina [2 ]
Makris, Michael [2 ]
Tiligada, Ekaterini [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pharmacol, M Asias 75, GR-11527 Athens, Greece
[2] Natl & Kapodistrian Univ Athens, Attikon Gen Univ Hosp, Dept Dermatol & Venereol 2, Allergy Unit D Kalogeromitros, Athens, Greece
关键词
Cyclooxygenase inhibitors; Drug hypersensitivity reactions; Histamine; Human peripheral blood; Non-steroidal anti-inflammatory drugs;
D O I
10.1159/000503968
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most prevalent causes of drug hypersensitivity reactions (DHRs), yet the underlying processes are far from clear. Despite the established role of histamine in allergic reactions, its precise implication in DHRs is elusive. Objectives: This study aimed to explore the connection of basal blood histamine levels to the reported NSAID hypersensitivity. Methods: Sixteen patients reporting hypersensitivity reactions to a single or multiple NSAIDs and/or paracetamol and 18 healthy volunteers serving as the normal control group enrolled in the study. The medical history was recorded and histamine was quantified spectrophotofluorometrically in whole peripheral blood and plasma. Results: Compared to the normal group, plasma but not whole blood histamine levels were significantly higher in patients (p < 0.001), mainly in the subgroup reporting hypersensitivity to a single agent (p < 0.001). Plasma histamine levels were significantly correlated with the culprit drug selectivity for cyclooxygenase (COX) isozymes (p < 0.001), with higher levels being obtained in patients reporting reactions to COX-1 than to COX-2 selective inhibitors (p < 0.05). Conclusions: The findings provide first evidence connecting basal blood histamine levels to the reported NSAID-triggered DHRs. Prospective studies are expected to decipher the contribution of histamine-associated parameters to the mechanisms underlying DHRs. (C) 2019 S. Karger AG, Basel
引用
收藏
页码:24 / 30
页数:7
相关论文
共 17 条
[1]   The Diamine Oxidase Gene Is Associated with Hypersensitivity Response to Non-Steroidal Anti-Inflammatory Drugs [J].
Agundez, Jose A. G. ;
Ayuso, Pedro ;
Cornejo-Garcia, Jose A. ;
Blanca, Miguel ;
Torres, Maria J. ;
Dona, Inmaculada ;
Salas, Maria ;
Blanca-Lopez, Natalia ;
Canto, Gabriela ;
Rondon, Carmen ;
Campo, Paloma ;
Laguna, Jose J. ;
Fernandez, Javier ;
Martinez, Carmen ;
Garcia-Martin, Elena .
PLOS ONE, 2012, 7 (11)
[2]   Serum Baseline Tryptase Level as a Marker for the Severity of Anaphylaxis [J].
Aniceto, Vinicius ;
Dias, Marina M. ;
Melo, Janaina M. L. ;
Trevisan-Neto, Orlando ;
Aragon, Davi C. ;
Maia, Luana S. M. ;
Moreno, Adriana S. ;
Arruda, Luisa Karla .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2019, 179 (03) :201-208
[3]  
ASAD SI, 1987, ANN ALLERGY, V59, P219
[4]  
Bando Tomoyuki, 2017, Biochem Biophys Rep, V10, P82, DOI 10.1016/j.bbrep.2017.03.004
[5]   NSAIDs hypersensitivity: questions not resolved [J].
Blanca-Lopez, Natalia ;
Somoza-Alvarez, Maria L. ;
Bellon, Teresa ;
Amo, Gemma ;
Canto, Gabriela ;
Blanca, Miguel .
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2018, 18 (04) :291-301
[6]   Reported Incidence of Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs in the Electronic Health Record [J].
Blumenthal, Kimberly G. ;
Lai, Kenneth H. ;
Wickner, Paige G. ;
Goss, Foster R. ;
Seger, Diane L. ;
Slight, Sarah P. ;
Topaz, Maxim ;
Chang, Frank Y. ;
Zhou, Li .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 137 (02) :AB196-AB196
[7]   Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients [J].
Boehm, Thomas ;
Reiter, Birgit ;
Ristl, Robin ;
Petroczi, Karin ;
Sperr, Wolfgang ;
Stimpfl, Thomas ;
Valent, Peter ;
Jilma, Bernd .
ALLERGY, 2019, 74 (03) :583-593
[8]   Comparable profiles of serum histamine and IgG4 levels in allergic beekeepers [J].
Chliva, C. ;
Aggelides, X. ;
Makris, M. ;
Katoulis, A. ;
Rigopoulos, D. ;
Tiligada, E. .
ALLERGY, 2015, 70 (04) :457-460
[9]   What we know about nonsteroidal anti-inflammatory drug hypersensitivity [J].
Duy Le Pham ;
Kim, Ji-Hye ;
Tu Hoang Kim Trinh ;
Park, Hae-Sim .
KOREAN JOURNAL OF INTERNAL MEDICINE, 2016, 31 (03) :417-432
[10]   Real World Evidence: Can We Really Expect It to Have Much Influence? [J].
Evans, Keith .
DRUGS-REAL WORLD OUTCOMES, 2019, 6 (02) :43-45