Immunoadsorption for autoimmune encephalitis

被引：19

作者：

Fassbender, Cordula ^{[1
]}

Klingel, Reinhard ^{[1
]}

Koehler, Wolfgang ^{[2
]}

机构：

[1] Apheresis Res Inst, Stadtwaldgurtel 77, D-50935 Cologne, Germany

[2] Specialist Hosp Hubertusburg, Dept Neurol & Neurol Intens Care Med, Wermsdorf, Germany

来源：

ATHEROSCLEROSIS SUPPLEMENTS | 2017年 / 30卷

关键词：

Autoimmune encephalitis; Tryptophan immunoadsorption; Plasma exchange; NMDAR autoantibody; THERAPEUTIC PLASMA-EXCHANGE; NMDA RECEPTOR ENCEPHALITIS; PARANEOPLASTIC LIMBIC ENCEPHALITIS; GATED POTASSIUM CHANNELS; TRYPTOPHAN IMMUNOADSORPTION; MULTIPLE-SCLEROSIS; ANTIBODIES; APHERESIS; PLASMAPHERESIS; DIAGNOSIS;

D O I：

10.1016/j.atherosclerosissup.2017.05.041

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Autoimmune encephalitis is a severe inflammatory disorder of the brain. The discovery that several non-infectious forms of encephalitis are associated with autoantibodies was a breakthrough in the care of this previously untreatable group of patients. The correlation of antibody type and titer with pattern and severity of symptoms was essential for the initiation of immunotherapies. First line therapy consists of steroids, intravenous immunoglobulins, plasma exchange or immunoadsorption. Rapid elimination of autoantibodies using selective immunoadsorption and avoiding the disadvantage of plasma substitution is a pathophysiologically guided therapeutic approach, and has been proven to be an effective therapeutic option as part of multimodal immunotherapy. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：257 / 263

页数：7

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