Isl1 Is required for multiple aspects of motor neuron development

被引：76

作者：

Liang, Xingqun ^{[2
]}

Song, Mi-Ryoung ^{[3
,4
]}

Xu, ZengGuang ^{[2
]}

Lanuza, Guillermo M. ^{[5
]}

Liu, Yali ^{[2
]}

Zhuang, Tao ^{[2
]}

Chen, Yihan ^{[2
]}

Pfaff, Samuel L. ^{[6
]}

Evans, Sylvia M. ^{[1
,3
,4
]}

Sun, Yunfu ^{[2
]}

机构：

[1] Univ Calif San Diego, Skaggs Sch Pharm, Dept Med, La Jolla, CA 92093 USA

[2] Tongji Univ, Sch Med, East Hosp, Minist Educ,Key Lab Arrhythmia, Shanghai 200120, Peoples R China

[3] Gwangju Inst Sci & Technol, Sch Life Sci, Bioimaging Res Ctr, Kwangju 500712, South Korea

[4] Gwangju Inst Sci & Technol, Sch Life Sci, Cell Dynam Res Ctr, Kwangju 500712, South Korea

[5] Fdn Inst Leloir, RA-1405 Buenos Aires, DF, Argentina

[6] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2011年 / 47卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Motor neuron; V2; interneuron; Cranial ganglia; Cell death; Isl1; Axon growth; HOMEOBOX GENE ISLET-1; EMBRYONIC ZEBRAFISH; AXON GUIDANCE; TRANSCRIPTIONAL CODES; INTERNEURON IDENTITY; HOMEODOMAIN PROTEIN; CHOLINERGIC NEURONS; PATHWAY SELECTION; SPINAL-CORD; STEM-CELLS;

D O I：

10.1016/j.mcn.2011.04.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1 Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：215 / 222

页数：8

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