Response of booster dose of Cuban recombinant hepatitis-B vaccine in nonresponder and hyporesponder children

被引:0
作者
Dahifar, Hossein [1 ]
Mousavi, Farideh
Ghorbani, Aboulphazl [1 ]
机构
[1] Shahid Beheshti Univ Med Sci & Hlth Sci, Shohada Med Ctr, Dept Pediat, Tehran, Iran
关键词
hepatitis B virus; vaccination; Cuban vaccine; hyporesponders; nonresponders;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Acute hepatitis B infection can debilitate a patient for weeks and occasionally has a fatal outcome, white chronic infection is a major threat to the individual. Objective: To assess response of nonresponder and hyporesponder children to booster dose of Cuban recombinant hepatitis B vaccine. Subjects and Methods: An interventional, descriptive study has been conducted on children who had been immunized with Cuban recombinant Hepatitis B vaccine and their antibody titers were <= 10mIU/ml (nonresponder) and 10-100mIU/ml (hyporesponder) administered booster dose of the same vaccine in their Deltoid muscles. Results: The response of 141 children with the mean age of 1.9 years to booster dose of vaccine were 94.3% and 100% vaccinees with the first and second booster dose of vaccination respectively. The anti-HBs titer in nonresponders and hyporesponders; were 468 346 and 783 346mIU/ml respectively with significant differences between two groups (P=0.001). Conclusion: This study demonstrate moderately increase antibody production in the majority of vaccinees with single supplementary vaccine.
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页码:23 / 26
页数:4
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