Proliferative and cell fate effects of Hedgehog signaling in the vertebrate retina

被引：41
作者：
Wallace, Valerie A. [1 ,2 ,3 ]
机构：
[1] Ottawa Hlth Res Inst, Program Mol Med, Ottawa, ON K1H 8L6, Canada
[2] Univ Ottawa, Inst Eye, Ottawa, ON, Canada
[3] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada
来源：
BRAIN RESEARCH | 2008年 / 1192卷
基金：
加拿大健康研究院;
关键词：
Hedgehog; proliferation; progenitor; retinal ganglion cell; cell fate; retina; development; muller glia; differentiation; Gli; Hes1; patched; neurogenesis;
D O I：
10.1016/j.brainres.2007.06.018
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The retina is an excellent system for delving into the question of how cell fate, number and organization are regulated in the central nervous system. Multipotential progenitor cells in the immature retina proliferate, exit the cell cycle and generate neurons and one glial cell type in a prescribed temporal sequence. While some aspects of progenitor behavior are controlled cell intrinsically, extrinsic signals present in the retina environment have been shown to impact on proliferation, differentiation and cell fate of progenitors. Intercellular signaling proteins of the Hedgehog (Hh) family regulate several aspects of visual system development in vertebrates-ranging from early eye field patterning to retinal and optic nerve development. This review highlights the role of Hh signaling on retinal progenitor proliferation and diversification. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：61 / 75
页数：15
相关论文
共 154 条
[1]   Identification of neural progenitors in the adult mammalian eye [J].
Ahmad, I ;
Tang, L ;
Pham, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 270 (02) :517-521
[2]   The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal [J].
Alcedo, J ;
Ayzenzon, M ;
VonOhlen, T ;
Noll, M ;
Hooper, JE .
CELL, 1996, 86 (02) :221-232
[3]   Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins [J].
Alexandre, C ;
Jacinto, A ;
Ingham, PW .
GENES & DEVELOPMENT, 1996, 10 (16) :2003-2013
[4]  
Alexiades MR, 1997, DEVELOPMENT, V124, P1119
[5]  
Alexiades MR, 1996, DEV DYNAM, V205, P293, DOI 10.1002/(SICI)1097-0177(199603)205:3<293::AID-AJA9>3.0.CO
[6]  
2-D
[7]   The emergent design of the neural tube:: prepattern, SHH morphogan and GLI code [J].
Altaba, AR ;
Nguyên, V ;
Palma, V .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (05) :513-521
[8]  
ALTSHULER D, 1993, DEVELOPMENT, V119, P1317
[9]  
ALTSHULER D, 1992, DEVELOPMENT, V114, P947
[10]   Hedgehog signaling in vertebrate eye development: a growing puzzle [J].
Amato, MA ;
Boy, S ;
Perron, M .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (7-8) :899-910
12345678910