Iron-catalyzed trifluoromethylation of vinylcyclopropanes: facile synthesis of CF3-containing dihydronaphthalene derivatives

被引：35

作者：

Li, Zong-Rui ^{[1
,2
]}

Bao, Xing-Xing ^{[3
,4
]}

Sun, Jian ^{[1
,2
]}

Shen, Jing ^{[1
,2
]}

Wu, Dun-Qi ^{[1
,2
]}

Liu, Yan-Kai ^{[1
,2
]}

Deng, Qing-Hai ^{[1
,2
]}

Liu, Feng ^{[3
,4
]}

机构：

[1] Shanghai Normal Univ, Educ Minist, Key Lab Resource Chem, Shanghai 200234, Peoples R China

[2] Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

[3] Soochow Univ, Jiangsu Key Lab Translat Res & Therapy Neuropsych, 199 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China

[4] Soochow Univ, Dept Med Chem, Coll Pharmaceut Sci, 199 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2016年 / 3卷 / 08期

基金：

中国国家自然科学基金;

关键词：

PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; BOND-FORMATION; OXIDATIVE TRIFLUOROMETHYLATION; ELECTROPHILIC TRIFLUOROMETHYLATION; BIOLOGICAL EVALUATION; CARBONYL-COMPOUNDS; GENERAL-SYNTHESIS; TERMINAL ALKENES; COPPER; FLUORINATION;

D O I：

10.1039/c6qo00166a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient Fe(II)-catalyzed trifluoromethylation of vinylcyclopropanes was successfully developed. A series of CF3-containing dihydronaphthalene derivatives were prepared in moderate to high yields (up to 96%) under mild reaction conditions using the Togni reagent as the CF3 source.

引用

页码：934 / 938

页数：5

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