RETRACTED: MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells (Retracted Article)

被引：39

作者：

Wang, Hongwei ^{[1
]}

Yan, Chunhua ^{[1
]}

Shi, Xiaodong ^{[2
]}

Zheng, Jiaolin ^{[2
]}

Deng, Lili ^{[3
]}

Yang, Lei ^{[4
]}

Yu, Fangfei ^{[1
]}

Yang, Yuandi ^{[1
]}

Shao, Yuxia ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Resp, Harbin 150081, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, Harbin 150081, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 2, Dept Oncol, Harbin 150081, Peoples R China

[4] Harbin Med Univ, Affiliated Hosp 2, Dept Thorac Surg, Harbin 150081, Peoples R China

来源：

FEBS LETTERS | 2015年 / 589卷 / 07期

关键词：

Non-small cell lung cancer; MicroRNA-575; BLID; Oncogene; EXPRESSION PROFILE; DIFFERENTIATION; PROLIFERATION; METASTASIS; PROTEIN; BRCC2; GENE;

D O I：

10.1016/j.febslet.2015.02.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was designed to detect miR-575 expression and function in non-small cell lung cancer (NSCLC). A higher expression of miR-575 in NSCLC tissues was observed compared with adjacent non-neoplastic tissues. Furthermore, re-introduction of miR-575 significantly promoted cell proliferation, migration, and invasion in the NSCLC line. Moreover, we showed that BLID is negatively regulated by miR-575 at the posttranscriptional level, via a specific target site within the 3'UTR. Overexpression of BLID counteracted miR-575-induced proliferation and invasion in NSCLC cells. The expression of BLID is frequently downregulated in NSCLC tumors and cell lines and inversely correlates with miR-575 expression. The findings of this study contribute to the current understanding of the functions of miR-575 in NSCLC. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：805 / 811

页数：7

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