Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function

被引：116

作者：

Sengupta, Prabuddha ^{[1
]}

Baird, Barbara ^{[1
]}

Holowka, David ^{[1
]}

机构：

[1] Cornell Univ, Baker Lab, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 05期

关键词：

cholesterol; liquid ordered; lipid probes; IgE receptors; mast cells;

D O I：

10.1016/j.semcdb.2007.07.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Novel biophysical approaches combined with modeling and new biochemical data have helped to recharge the lipid raft field and have contributed to the generation of a refined model of plasma membrane organization. In this review, we summarize new information in the context of previous literature to provide new insights into the spatial organization and dynamics of lipids and proteins in the plasma membrane of live cells. Recent findings of large-scale separation of liquid-ordered and liquid-disordered phases in plasma membrane vesicles demonstrate this capacity within the complex milieu of plasma membrane proteins and lipids. Roles for membrane heterogeneity and reorganization in immune cell activation are discussed in light of this new information. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：583 / 590

页数：8

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