Role of stress in chronic fatigue

In this review article a novel approach to the explanation of chronic fatigue is presented. It has long been known that patients suffering from chronic fatigue syndrome (CFS) have reported increased occurrencesof traumatic experiences early in life compared to healthy individuals. Such experiences have been found to substantially impact on biological regulation processes later in life and thus alter sensitivity to stressful stimuli in adulthood. In CFS research has shown that patients display altered endocrine and immune stress regulation. A summary of current research in this area is given and the role of both childhood and adulthood stressors in biological regulation processes in CFS is discussed.