Trypanocidal tetrahydrofuran lignans from Peperomia blanda

被引：38

作者：

Felippe, Lidiane Gaspareto ^{[1
]}

Baldoqui, Debora Cristina ^{[1
]}

Kato, Massuo Jorge ^{[2
]}

Bolzani, Vanderlan da Silva ^{[1
]}

Guimaraes, Elsie Franklin ^{[3
]}

Cicarelli, Regina Maria Barreto ^{[4
]}

Furlan, Maysa ^{[1
]}

机构：

[1] Univ Estadual Paulista, Inst Quim, BR-14800 Araraquara, SP, Brazil

[2] Univ Sao Paulo, Inst Quim, BR-05599 Sao Paulo, Brazil

[3] Inst Pesquisas Jardim Rio Janeiro, Rio De Janeiro, Brazil

[4] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801 Araraquara, SP, Brazil

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Peperomia blanda; Piperaceae; tetrahydrofuran lignans; structural elucidation; trypanocidal activity;

D O I：

10.1016/j.phytochem.2007.08.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five tetrahydrofuran lignans and two known flavones were isolated from the aerial parts of Peperomia blanda. The structures of the isolated lignans were elucidated by interpretation of their spectroscopic data, including by gHMQC and gHMBC. The relative and absolute configurations of the isolates were determined from NOESY interactions and optical properties, respectively. Four of the lignans were diastercomeric whilst one was of mixed biosynthetic origin. All but one of the lignans exhibited high in vitro trypanocidal activity when assayed against epimastigotes of Trypanosoma cruzi strain Y. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：445 / 450

页数：6

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