Cell Fate Plug and Play: Direct Reprogramming and Induced Pluripotency

被引：94

作者：

Chambers, Stuart M. ^{[1
,2
]}

Studer, Lorenz ^{[1
,2
]}

机构：

[1] Sloan Kettering Inst, Ctr Stem Cell Biol, New York, NY 10065 USA

[2] Sloan Kettering Inst, Dev Biol Program, New York, NY 10065 USA

来源：

CELL | 2011年 / 145卷 / 06期

关键词：

EMBRYONIC STEM-CELLS; DIRECT CONVERSION; DEFINED FACTORS; IPS CELLS; FIBROBLASTS; EXPRESSION; DIFFERENTIATION; PROGENITORS;

D O I：

10.1016/j.cell.2011.05.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Building on the discovery that MyoD expression reprograms fibroblasts into muscle, three papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors without first passing the cells through a pluripotent state. Here we discuss the advantages and challenges of harnessing this direct reprogramming method for regenerative medicine.

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收藏

页码：827 / 830

页数：4

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