Pinning down signaling in the immune system: The role of the peptidyl-prolyl isomerase Pin1 in immune cell function

被引：40

作者：

Esnault, Stephane ^{[1
]}

Shen, Zong-Jian ^{[1
]}

Malter, James S. ^{[1
]}

机构：

[1] UW Madison, Sch Med Publ Hlth, Madison, WI USA

来源：

CRITICAL REVIEWS IN IMMUNOLOGY | 2008年 / 28卷 / 01期

关键词：

Pin1; mRNA decay; eosinophil; lymphocyte; asthma; transplantation;

D O I：

10.1615/CritRevImmunol.v28.i1.30

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so differentially from the related PPIases, cyclophilinA and FKBP. This review describes how Pin1 modulates cytokine expression by activated T cells and eosinophils and participates in T-cell and eosinophil apoptotic decisions both in vitro and in vivo. We highlight several possible immunologic diseases, including asthma, as well as organ transplant rejection, where anti-Pin1 therapeutics may be of value.

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收藏

页码：45 / 60

页数：16

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共 130 条

[81] Genotoxic stress regulates expression of the proto-oncogene Bc16 in germinal center B cells [J].

Phan, Ryan T. ;

Saito, Masumichi ;

Kitagawal, Yukiko ;

Means, Anthony R. ;

Dalla-Favera, Riccardo .

NATURE IMMUNOLOGY, 2007, 8 (10) :1132-1139

[82] Synergistic effect of low dose cyclosporine A and human interleukin 10 overexpression on acute rejection in rat lung allotransplantation [J].

Pierog, J ;

Gazdhar, A ;

Stammberger, U ;

Gugger, M ;

Hyde, S ;

Mathiesen, I ;

Grodzki, T ;

Schmid, RA .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2005, 27 (06) :1030-1035

[83] CONFIRMATION OF THE EXISTENCE OF A 3RD FAMILY AMONG PEPTIDYL-PROLYL CIS/TRANS ISOMERASES - AMINO-ACID-SEQUENCE AND RECOMBINANT PRODUCTION OF PARVULIN [J].

RAHFELD, JU ;

RUCKNAGEL, KP ;

SCHELBERT, B ;

LUDWIG, B ;

HACKER, J ;

MANN, K ;

FISCHER, G .

FEBS LETTERS, 1994, 352 (02) :180-184

[84] A NOVEL PEPTIDYL-PROLYL CIS/TRANS ISOMERASE FROM ESCHERICHIA-COLI [J].

RAHFELD, JU ;

SCHIERHORN, A ;

MANN, K ;

FISCHER, G .

FEBS LETTERS, 1994, 343 (01) :65-69

[85] Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference [J].

Raineri, I ;

Wegmueller, D ;

Gross, B ;

Certa, U ;

Moroni, C .

NUCLEIC ACIDS RESEARCH, 2004, 32 (04) :1279-1288

[86] Turnover and translation of in vitro synthesized messenger RNAs in transfected, normal cells [J].

Rajagopalan, LE ;

Malter, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (33) :19871-19876

[87] MUTATION OF UNIQUE REGION OF BRUTONS TYROSINE KINASE IN IMMUNODEFICIENT XID MICE [J].

RAWLINGS, DJ ;

SAFFRAN, DC ;

TSUKADA, S ;

LARGAESPADA, DA ;

GRIMALDI, JC ;

COHEN, L ;

MOHR, RN ;

BAZAN, JF ;

HOWARD, M ;

COPELAND, NG ;

JENKINS, NA ;

WITTE, ON .

SCIENCE, 1993, 261 (5119) :358-361

[88] Cytokines and chemoattractants in allergic inflammation [J].

Romagnani, S .

MOLECULAR IMMUNOLOGY, 2002, 38 (12-13) :881-885

[89] The role of cyclin-dependent kinases in T-cell development, proliferation, and function [J].

Rowell, Emily A. ;

Wells, Andrew D. .

CRITICAL REVIEWS IN IMMUNOLOGY, 2006, 26 (03) :189-212

[90] A functional role for mitochondrial protein kinase Cα in Bcl2 phosphorylation and suppression of apoptosis [J].

Ruvolo, PP ;

Deng, XM ;

Carr, BH ;

May, WS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (39) :25436-25442

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