Effects of different periods of gastric ischemia on liver as a remote organ

被引：1

作者：

Baron Magalhaes, Maria Angelica ^{[1
]}

Petroianu, Andy ^{[2
]}

Afonso Barbosa, Alfredo Jose ^{[3
]}

Figueiredo, Juliano Alves ^{[1
]}

Alberti, Luiz Ronaldo ^{[1
]}

Ribas Filho, Jurandir Marcondes ^{[4
]}

机构：

[1] Univ Fed Minas Gerais, Fac Med, Dept Surg, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Fac Med, Dept Surg, CNPq 1B, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Fac Med, Dept Pathol, Belo Horizonte, MG, Brazil

[4] Fac Evangel Parana FEPAR, Fac Med, Dept Surg, Curitiba, PR, Brazil

来源：

ACTA CIRURGICA BRASILEIRA | 2018年 / 33卷 / 11期

关键词：

Stomach; Ischemia; Inflammation; Liver; Rabbits; SEPSIS; REPERFUSION; DYSFUNCTION; MANAGEMENT; INJURY;

D O I：

10.1590/s0102-865020180110000003

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Purpose: To evaluate the hepatic changes associated with gastric ischemia. Methods: Thirty male rabbits were studied, distributed in 3 groups (n=10). Group 1: ligature and section of the gastric vasculature and removal of the liver after three hours; Group 2: ligature and section of the gastric vasculature and removal of the liver after 6 hours; Group 3: ligature and section of the gastric vasculature and removal of the liver after 12 hours. Blood samples were collected immediately before surgery and after the determined time of ischemia in each group to evaluate the hepatic function. After the death of the rabbits, the liver was removed for macro and microscopic study. Results: An increase in aminotransferases and bilirubin occurred in groups 2 and 3. Total protein and albumin diminished in all of the animals. All of the rabbits from groups 2 and 3 presented hepatocellular necrosis. Conclusion: The devascularization of the stomach for a period of above three hours is associated with hepatic morphological and functional disorders.

引用

页码：964 / 974

页数：11

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