Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults

被引：21

作者：

Ponsford, Mark J. ^{[1
,2
]}

Jefferies, Rhys ^{[3
,4
]}

Davies, Chris ^{[5
]}

Farewell, Daniel ^{[6
]}

Humphreys, Ian R. ^{[2
,7
]}

Jolles, Stephen ^{[1
]}

Fairbairn, Sara ^{[3
,8
]}

Lewis, Keir ^{[9
,10
]}

Menzies, Daniel ^{[11
]}

Benjamin, Amit ^{[12
]}

Thaivalappil, Favas ^{[13
]}

Williams, Chris ^{[14
]}

Barry, Simon M. ^{[15
]}

机构：

[1] Univ Wales Hosp, Immunodeficiency Ctr Wales, Cardiff, Wales

[2] Cardiff Univ, Sch Med, Div Infect Immun & Inflammat, Cardiff, Wales

[3] NHS Wales Collaborat, Resp Hlth Implementat Grp, Swansea, W Glam, Wales

[4] Swansea Univ, Sch Med, Inst Life Sci, Swansea, W Glam, Wales

[5] Inst Clin Sci & Technol, Cardiff, Wales

[6] Cardiff Univ, Sch Med, Div Populat Med, Cardiff, Wales

[7] Cardiff Univ, Syst Immun Res Inst, Cardiff, Wales

[8] Aneurin Bevan Hlth Board, Dept Resp Med, Newport, Shrops, England

[9] Hywel Dda Univ Hlth Board, Prince Philip Hosp, Dept Med, Carmarthen, Dyfed, Wales

[10] Swansea Univ, Coll Human & Hlth Sci, Swansea, W Glam, Wales

[11] Betsi Cadwaladr Univ Hlth Board, Dept Resp Med, Bangor, Gwynedd, Wales

[12] Cwm Taf Univ Hlth Board, Dept Resp Med, Abercynon, Wales

[13] Swansea Bay Univ Hlth Board, Dept Resp Med, Port Talbot, Wales

[14] Publ Hlth Wales, Ctr Communicable Dis Surveillance, Cardiff, Wales

[15] Cardiff & Vale Univ Hlth Board, Dept Resp Med, Cardiff, Wales

来源：

THORAX | 2021年 / 76卷 / 12期

关键词：

COVID-19; clinical epidemiology; infection control; viral infection; respiratory Infection; COPE;

D O I：

10.1136/thoraxjnl-2021-216964

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The burden of nosocomial SARS-CoV-2 infection remains poorly defined. We report on the outcomes of 2508 adults with molecularly-confirmed SARS-CoV-2 admitted across 18 major hospitals, representing over 60% of those hospitalised across Wales between 1 March and 1 July 2020. Inpatient mortality for nosocomial infection ranged from 38% to 42%, consistently higher than participants with community-acquired infection (31%-35%) across a range of case definitions. Those with hospital-acquired infection were older and frailer than those infected within the community. Nosocomial diagnosis occurred a median of 30 days following admission (IQR 21-63), suggesting a window for prophylactic or postexposure interventions, alongside enhanced infection control measures.

引用

页码：1246 / 1249

页数：4

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