Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

被引:31
作者
Cao, Mengshu [1 ]
Swigris, Jeffery J. [2 ]
Wang, Xin [1 ]
Cao, Min [1 ]
Qiu, Yuying [1 ]
Huang, Mei [1 ]
Xiao, Yonglong [1 ]
Cai, Hourong [1 ]
机构
[1] Affiliated Nanjing Univ, Nanjing Drum Tower Hosp, Dept Resp Med, Sch Med, Nanjing 210008, Jiangsu, Peoples R China
[2] Univ Colorado, Natl Jewish Hlth, Dept Med, Interstitial Lung Dis Program, Denver, CO 80206 USA
基金
中国国家自然科学基金;
关键词
ASSOCIATION; HEPATITIS; DISEASE; CELLS; GENE; MICE; KL-6;
D O I
10.1155/2016/6940480
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Background. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. Some patients will experience acute exacerbation (AE) and fatal outcomes. Methods. The study included 30 AE-IPF patients, 32 stable IPF (S-IPF) patients, and 12 healthy controls. We measured the plasma concentrations of leptin and KL-6. Simple correlation was used to assess associations between leptin and other variables. Plasma leptin levels were compared between AE-IPF and S-IPF subjects, decedents, and survivors. Kaplan-Meier curves were used to display survival and Cox proportional hazards regression was used to examine risk factors for survival. Results. In subjects with AE-IPF, plasma leptin was significantly greater than in subjects with S-IPF (p = 0.0003) or healthy controls (p < 0.0001). Plasma leptin was correlated with BMI, KL-6, LDH, CRP, and PaO2/FiO(2) (p = 0.007; p = 0.005; p = 0.003; p = 0.033; and p = 0.032, resp.). Plasma leptin was significantly greater in 33 decedents than in the 23 survivors (p = 0.007). Multivariate Cox regression analysis showed leptin (>13.79 ng/mL) was an independent predictor of survival (p = 0.004). Conclusions. Leptin could be a promising plasma biomarker of AE-IPF occurrence and predictor of survival in IPF patients.
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页数:7
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