Development of amphotericin B-loaded propionate Sterculia striata polysaccharide nanocarrier

被引:22
|
作者
Sombra, Fernando M. [1 ]
Richter, Ana Rosa [1 ]
de Araujo, Alyne Rodrigues [2 ]
Silva Ribeiro, Fabio de Oliveira [2 ]
Souza Mendes, Josilayne de Fatima [3 ]
dos Santos Fontenelle, Raquel Oliveira [3 ]
da Silva, Durcilene Alves [2 ]
Paula, Haroldo C. B. [1 ]
Feitosa, Judith P. A. [1 ]
Goycoolea, Francisco M. [4 ]
de Paula, Regina C. M. [1 ]
机构
[1] UFC CEP, Dept Organ & Inorgan Chem, Caixa Postal 6021,Humberto Monte S-N, BR-60455760 Fortaleza, Ceara, Brazil
[2] Univ Fed Piaui, Nucl Pesquisa Biodiversidade & Biotecnol, BIOTEC, Campus Ministro Reis Velloso, Teresina, Malaysia
[3] Univ Estadual Vale Acarau, Ctr Ciencias Agr & Biol, Curso Ciencias Biol, Sobral, Brazil
[4] Univ Leeds, Sch Food Sci & Nutr, Leeds LS16 7PA, W Yorkshire, England
关键词
Sterculia striata polysaccharide; Nanocapsules; Antifungal; Drug delivery; SOLID LIPID NANOPARTICLES; IN-VITRO; PICKERING EMULSION; CASHEW GUM; FORMULATION; TOXICITY; DELIVERY; CARRIERS; RELEASE; ENCAPSULATION;
D O I
10.1016/j.ijbiomac.2019.10.053
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This work was aimed at the production and characterization of a new nanocarrier based on a Sterculia striate polysaccharide (SSP) modified via acylation reaction with propionic anhydride. Nanocapsules of propionated SSP (PSSP) were produced via spontaneous nanoemulsification process and tested as a potential amphotericin B (AMB) nanocarrier. Stable nanoparticles with a very low polydispersity index (0.08-0.29) and high zeta potential (zeta -42.7 to -53.8 mV) were obtained. Particle size was dependent on the degree of substitution and ranged from 205 to 286 nm. A nanocapsule with a degree of substitution (DS) of 2.53 (NCp 2.53) was selected for encapsulation, biocompatibility, and antifungal evaluation against Candida albicans strains. A maximum of 98.3% AMB encapsulation was achieved. Encapsulated AMB was in its monomeric form and showed good biocompatibility and antifungal activity against four C. albicans strains. Data indicate that PSSP has potential as a nanocarrier system for AMB. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码:1133 / 1141
页数:9
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