Metabolite profiling of human blood by surface-enhanced Raman spectroscopy for surgery assessment and tumor screening in breast cancer

被引：35

作者：

Lin, Duo ^{[1
]}

Wang, Yunyi ^{[2
]}

Wang, Tingyin ^{[2
]}

Zhu, Youzhi ^{[3
]}

Lin, Xueliang ^{[2
]}

Lin, Yao ^{[4
]}

Feng, Shangyuan ^{[2
]}

机构：

[1] Fujian Univ Tradit Chinese Med, Coll Integrated Tradit Chinese & Western Med, Fuzhou 350122, Fujian, Peoples R China

[2] Fujian Normal Univ, Key Lab Optoelect Sci & Technol Med, Fujian Prov Key Lab Photon Technol, Minist Educ,Digital Fujian Internet Of Things Lab, Fuzhou 350007, Fujian, Peoples R China

[3] Fujian Med Univ, Affiliated Hosp 1, Dept Thyroid & Breast Surg, Fuzhou 350001, Fujian, Peoples R China

[4] Fujian Normal Univ, Coll Life Sci, Fuzhou 350007, Fujian, Peoples R China

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2020年 / 412卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Surface-enhanced Raman spectroscopy; Silver nanoparticles; Blood analysis; Breast cancer; Surgery assessment; Screening; SCATTERING; SERUM; NANOPARTICLES; REDUCTION; PLASMA; DNA;

D O I：

10.1007/s00216-020-02391-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammography, a standard screening method for breast cancer, is effective for reducing the rate of death; however, it suffers from frequent false positive alarm and radiation risk. Besides, surgery treatment has a vital impact on the clinical outcomes of breast cancer, offering enormous benefits for breast cancer care and management. In this work, we analyzed the peripheral blood sample from breast cancer patients with pre- and post-surgery and healthy volunteers using label-free surface-enhanced Raman spectroscopy technology based on silver nanoparticles. Results showed that distinct patterns of blood belonging to specific subjects could be profiled, and corresponding accuracies of 95% and 100% were achieved by multivariate diagnostic algorithm for pre-surgery vs. post-surgery and pre-surgery vs. normal groups, respectively, providing a unique blood analysis method for surgery evaluation as well as tumor screening in breast cancer. Graphical abstract

引用

页码：1611 / 1618

页数：8

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