Retrospective analysis of high-dose chemotherapy followed by autologous stem cell transplantation for high-risk pediatric osteosarcoma

被引：2

作者：

Uemura, Suguru ^{[1
]}

Mori, Takeshi ^{[1
]}

Ishiko, Shinya ^{[1
]}

Takafuji, Satoru ^{[1
]}

Nino, Nanako ^{[1
]}

Yamamoto, Nobuyuki ^{[1
]}

Hayakawa, Akira ^{[2
]}

Nishimura, Noriyuki ^{[1
]}

Hara, Hitomi ^{[3
]}

Kawamoto, Teruya ^{[3
]}

Akisue, Toshihiro ^{[3
]}

Iijima, Kazumoto ^{[1
]}

机构：

[1] Kobe Univ, Dept Pediat, Grad Sch Med, Kobe, Hyogo, Japan

[2] Yodogawa Christians Hosp, Dept Palliat Med, Osaka, Japan

[3] Kobe Univ, Dept Orthpaed Surg, Grad Sch Med, Kobe, Hyogo, Japan

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2020年 / 37卷 / 04期

关键词：

Autologous stem cell transplantation; high-dose chemotherapy; osteosarcoma; HIGH-GRADE OSTEOSARCOMA; PROGNOSTIC-FACTORS; PREOPERATIVE CHEMOTHERAPY; EXTREMITIES; THERAPY; RESCUE;

D O I：

10.1080/08880018.2020.1729906

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The outcomes of osteosarcoma with poor prognostic factors, such as poor responders, metastatic disease at diagnosis, and relapsed or refractory disease, are poor. We reviewed the clinical records of the patients diagnosed with osteosarcoma at our institute between 2004 and 2018 who received high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) in our institute. Ten patients of osteosarcoma with poor responder, refractory status, and metastatic disease at diagnosis received high-dose chemotherapy followed by ASCT. Four patients underwent high-dose chemotherapy followed by ASCT with the conditioning regimen consisted of thiotepa and melphalan (MEL). Five patients underwent high-dose chemotherapy followed by ASCT with the conditioning regimen consisted of intravenous busulfan (BU) and MEL. One patient underwent tandem high-dose chemotherapy followed by ASCT with BU and MEL followed by carboplatin and etoposide. None of the ten patients died of regimen related toxicities. None of the five patients with poor responders who underwent high-dose chemotherapy followed by ASCT as part of consolidation therapy died of disease after ASCT. High-dose chemotherapy followed by ASCT might be effective for poor responders in osteosarcoma.

引用

页码：337 / 343

页数：7

共 18 条

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