Cetirizine as pH-dependent cross-reactant in a carbamazepine-specific immunoassay

被引：19

作者：

Bahlmann, Arnold ^{[1
]}

Falkenhagen, Jana ^{[1
]}

Weller, Michael G. ^{[1
]}

Panne, Ulrich ^{[1
,2
]}

Schneider, Rudolf J. ^{[1
]}

机构：

[1] BAM Fed Inst Mat Res & Testing, D-12489 Berlin, Germany

[2] Humboldt Univ, Dept Chem, D-12489 Berlin, Germany

来源：

ANALYST | 2011年 / 136卷 / 07期

关键词：

LINKED-IMMUNOSORBENT-ASSAY; TANDEM MASS-SPECTROMETRY; LIQUID-CHROMATOGRAPHY; METABOLITES; IDENTIFICATION; OXCARBAZEPINE; RESIDUE; ELISA; WATER;

D O I：

10.1039/c0an00928h

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

High performance liquid chromatography (HPLC) was hyphenated with a previously reported carbamazepine-specific enzyme-linked immunosorbent assay (ELISA) as a screening approach to water analysis in order to identify possible interferences from transformation products. Treated wastewater was analysed and three substances were recognized by the antibody besides carbamazepine: the metabolites 10,11-dihydro-10,11-epoxycarbamazepine and 2-hydroxycarbamazepine plus the structurally not obviously related antihistamine cetirizine. The molar cross-reactivity against cetirizine was found to be pH-dependent and assessed to be 400% at pH 4.5 and 22% at pH 10.5. Performing the ELISA at pH 10.5 greatly improved the accuracy when carbamazepine was determined in surface and wastewater samples.

引用

页码：1357 / 1364

页数：8

共 34 条

[1] Monitoring carbamazepine in surface and wastewaters by an immunoassay based on a monoclonal antibody [J].

Bahlmann, Arnold ;

Weller, Michael G. ;

Panne, Ulrich ;

Schneider, Rudolf J. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 395 (06) :1809-1820

[2] CARBAMAZEPINE 10, 11 EPOXIDE CONCENTRATIONS IN EPILEPTICS ON CARBAMAZEPINE ALONE AND IN COMBINATION WITH OTHER ANTI-CONVULSANTS [J].

BRODIE, MJ ;

FORREST, G ;

RAPEPORT, WG .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 16 (06) :747-750

[3]

*DTSCH I MED DOK I, 2009, AN THER CHEM KLASS T

[4] CONTAMINATION OF SURFACE, GROUND, AND DRINKING WATER FROM PHARMACEUTICAL PRODUCTION [J].

Fick, Jerker ;

Soederstrom, Hanna ;

Lindberg, Richard H. ;

Phan, Chau ;

Tysklind, Mats ;

Larsson, D. G. Joakim .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2009, 28 (12) :2522-2527

[5] Development of a direct competitive enzyme-linked immunosorbent assay for parathion residue in food samples [J].

Gui, Wen-Jun ;

Liu, Yi-Hua ;

Wang, Chun-Mei ;

Liang, Xiao ;

Zhu, Guo-Nian .

ANALYTICAL BIOCHEMISTRY, 2009, 393 (01) :88-94

[6] Novel identification of a sulfur-centered, radical-derived 5,5-dimethyl-1-pyrroline N-oxide nitrone adduct formed from the oxidation of DTT by LC/ELISA, LC/electrospray ionization-MS, and LC/tandem MS [J].

Guo, Q ;

Gao, GH ;

Qian, SY ;

Mason, RP .

CHEMICAL RESEARCH IN TOXICOLOGY, 2004, 17 (11) :1481-1490

[7]

HOUGARDY S, COSMOS COMP SMALL MO

[8]

Hu XR, 2003, Z KRIST-NEW CRYST ST, V218, P497

[9] Aquatic environmental assessment of the top 25 English prescription pharmaceuticals [J].

Jones, OAH ;

Voulvoulis, N ;

Lester, JN .

WATER RESEARCH, 2002, 36 (20) :5013-5022

[10] Identification of fungal metabolites of anticonvulsant drug carbamazepine [J].

Kang, Su-Il ;

Kang, Seo-Young ;

Hur, Hor-Gil .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2008, 79 (04) :663-669

← 1 2 3 4 →