A crucial role for the long non-coding RNA CASC11 in the pathogenesis of human cancers

被引：1

作者：

Zheng, Lian ^{[1
]}

Guan, Zhenjie ^{[2
]}

Xue, Miaomiao ^{[3
]}

机构：

[1] Zhengzhou Univ, Dept Oral & Maxillofacial Surg, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Dept Stomatol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

[3] Zhengzhou Univ, Dept Gen Dent, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China

来源：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2021年 / 13卷 / 09期

关键词：

Cancer; lncRNA; CASC11; prognosis; treatment; THERAPEUTIC TARGET; HNRNP-K; CELL-PROLIFERATION; GASTRIC-CANCER; LUNG-CANCER; LNCRNA; MIGRATION; PROMOTES; INVASION; ELEMENTS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long non-coding RNAs (lncRNAs) are non-coding RNAs more than 200 nucleotides in length. Although they do not encode proteins, lncRNAs can regulate gene expression at the transcriptional, post-transcriptional, and epigenetic levels. Emerging data show that lncRNAs are important for tumorigenesis and cancer progression. Cancer susceptibility candidate 11 (CASC11) is a prominent lncRNA that is upregulated in various types of cancers. Moreover, its overexpression correlates with larger tumor size, more advanced cancer stages, cancer metastasis, and poor overall survival for most types of cancer. Functionally, the knockdown of CASC11 can inhibit cell proliferation, invasion, and migration, while enhancing apoptosis through its regulation of gene expression and signaling pathways and its interactions with functional proteins. Here, we discuss the identification, expression, and function of CASC11. Additionally, we discuss the potential roles of CASC11 as a diagnostic biomarker, prognostic biomarker, and therapeutic target in various cancers.

引用

页码：10922 / 10932

页数：11

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