Role of microRNAs in the Regulation of Dendritic Cell Generation and Function

被引：35

作者：

Scalavino, Viviana ^{[1
]}

Liso, Marina ^{[1
]}

Serino, Grazia ^{[1
]}

机构：

[1] S de Bellis Res Hosp, Natl Inst Gastroenterol, I-70013 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 04期

关键词：

dendritic cells; miRNAs; inflammation; PERIPHERAL LYMPHOID ORGANS; HEMATOPOIETIC STEM-CELLS; DOWN-REGULATION; SELF-RENEWAL; STEADY-STATE; IN-VIVO; DIFFERENTIATION; EXPRESSION; MACROPHAGES; IDENTIFICATION;

D O I：

10.3390/ijms21041319

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendritic cells (DCs) are antigen-presenting cells with a key role in immune responses. They act as a link between the innate and adaptive systems and they can induce and maintain immunologic tolerance. DCs are subdivided into conventional and plasmacytoid DCs. These cell subsets originate from the same bone marrow precursors and their differentiation process is determined by several extrinsic and intrinsic factors, such as cytokines, transcription factors, and miRNAs. miRNAs are small non-coding RNAs that play a crucial role in modulating physiological and pathological processes mediated by DCs. miRNA deregulation affects many inflammatory conditions and diseases. The aim of this review was to underline the importance of miRNAs in inflammatory processes mediated by DCs in physiological and pathological conditions and to highlight their potential application for future therapies.

引用

页数：18

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