Association of genetic polymorphisms of CISH with the risk of pulmonary tuberculosis in Zahedan, Southeast Iran

Background: In the current study we aimed to find out the impact of cytokine-inducible Src homology 2 domain protein (CISH) gene polymorphisms on the risk of pulmonary tuberculosis (PTB) in a sample of Iranian population. Materials and methods: Polymorphisms of CISH rs2239751, rs414171, and rs6768300 were determined in 200 PTB patients and 200 healthy subjects using T-ARMS-PCR or PCR-RFLP method. Results: The results showed that rs414171 A>T genotypes significantly decreased the risk of PTB (OR = 0.16, 95% CI = 0.10-0.27, p < 0.0001, AT vs AA; OR = 0.31, 95% CI = 0.14-0.68, p < 0.0001, TT vs AA; OR = 0.19, 95% CI = 0.12-0.29, p < 0.0001, AT+TT vs AA; OR= 0.29, 95%CI = 0.20-0.42, p < 0.0001, T vs A). For rs6768300, the findings indicated that this variant decreased the risk of PTB (OR= 0.52, 95% CI = 0.33-0.82, p = 0.005, CG vs GG; OR= 0.57, 95% CI = 0.38-0.87, p = 0.012, C vs G). No significant association was observed between CISH rs2239751 polymorphism and risk/protection of PTB. Conclusion: Our findings indicated that CISH rs414171 and rs6768300 variants might be associated with protection from PTB. (C) 2016 Elsevier Editora Ltda.