Maternal use of fertility drugs and risk of cancer in children-A nationwide population- based cohort study in Denmark

被引:32
作者
Hargreave, Marie [1 ]
Jensen, Allan [1 ]
Nielsen, Thor Schutt Svane [1 ]
Colov, Emilie Palmgren [1 ]
Andersen, Klaus Kaae [2 ]
Pinborg, Anja [3 ]
Kjaer, Susanne Kruger [1 ,4 ]
机构
[1] Danish Canc Soc Res Ctr, Unit Virus Lifestyle & Genes, DK-2100 Copenhagen, Denmark
[2] Danish Canc Soc Res Ctr, Unit Stat Bioinformat & Registry, DK-2100 Copenhagen, Denmark
[3] Univ Copenhagen, Hvidovre Hosp, Dept Obstet & Gynecol, DK-2650 Hvidovre, Denmark
[4] Univ Copenhagen, Rigshosp, Dept Obstet & Gynecol, DK-2100 Copenhagen, Denmark
关键词
Infertility; fertility treatment; childhood cancer; assisted reproduction technology; progesterone; IN-VITRO FERTILIZATION; ONCOLOGY GROUP-REPORT; CHILDHOOD-CANCER; INFERTILITY TREATMENT; PARENTAL INFERTILITY; BIRTH CHARACTERISTICS; ACUTE-LEUKEMIA; YOUNG-ADULTS; NEUROBLASTOMA; EUROPE;
D O I
10.1002/ijc.29235
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Large population-based studies are needed to examine the effect of maternal use of fertility drugs on the risk of cancer in children, while taking into account the effect of the underlying infertility. A cohort of 123,322 children born in Denmark between 1964 and 2006 to 68,255 women who had been evaluated for infertility was established. We used a case-cohort design and calculated hazard ratios (HRs) for cancer in childhood (0-19 years) and in young adulthood (20-29 years) associated with maternal use of six groups of fertility drugs (clomiphene, gonadotropins [i.e., human menopausal gonadotropins and follicle-stimulating hormone], gonadotropin-releasing hormone analogs, human chorionic gonadotropins, progesterone and other fertility drugs). We found no statistically significant association between maternal use of fertility drugs and risk for overall cancer in childhood or young adulthood. However, with regard to specific cancers in childhood, our results showed that maternal use of progesterone before childbirth markedly increased the risks of their offspring for acute lymphocytic leukemia (any use: HR, 4.95; 95% CI, 1.69-14.54;three cycles of use: HR, 9.96; 95% CI, 2.63-37.77) and for sympathetic nervous system tumors (any use: HR, 5.79; 95% CI, 1.23-27.24;three cycles of use: HR, 8.51; 95% CI, 1.72-42.19). These findings show that maternal use of progesterone may increase the risk for specific cancers in the offspring. Additional large epidemiological studies are urgently needed to confirm our finding.
引用
收藏
页码:1931 / 1939
页数:9
相关论文
共 44 条
[1]   A CLASSIFICATION SCHEME FOR CHILDHOOD-CANCER [J].
BIRCH, JM ;
MARSDEN, HB .
INTERNATIONAL JOURNAL OF CANCER, 1987, 40 (05) :620-624
[2]   Childhood tumor risk after treatment with ovulation-stimulating drugs [J].
Brinton, LA ;
Kjær, SK ;
Thomsen, BL ;
Sharif, HF ;
Graubard, BI ;
Olsen, JH ;
Bock, JE .
FERTILITY AND STERILITY, 2004, 81 (04) :1083-1091
[3]   Incidence of cancer in children born after in-vitro fertilization [J].
Bruinsma, F ;
Venn, A ;
Lancaster, P ;
Speirs, A ;
Healy, D .
HUMAN REPRODUCTION, 2000, 15 (03) :604-607
[4]   CELL-PROLIFERATION IN CARCINOGENESIS [J].
COHEN, SM ;
ELLWEIN, LB .
SCIENCE, 1990, 249 (4972) :1007-1011
[5]   Cancer incidence in children conceived with assisted reproduction technology [J].
Doyle, P ;
Bunch, KJ ;
Beral, V ;
Draper, GJ .
LANCET, 1998, 352 (9126) :452-453
[6]   Epigenetics in cancer: Targeting chromatin modifications [J].
Ellis, Leigh ;
Atadja, Peter W. ;
Johnstone, Ricky W. .
MOLECULAR CANCER THERAPEUTICS, 2009, 8 (06) :1409-1420
[7]   Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE [J].
Ferraretti, A. P. ;
Goossens, V. ;
Kupka, M. ;
Bhattacharya, S. ;
de Mouzon, J. ;
Castilla, J. A. ;
Erb, K. ;
Korsak, V. ;
Andersen, A. Nyboe .
HUMAN REPRODUCTION, 2013, 28 (09) :2318-2331
[8]   Are children born after infertility treatment at increased risk of retinoblastoma? [J].
Foix-L'Helias, L. ;
Aerts, I. ;
Marchand, L. ;
Lumbroso-Le Rouic, L. ;
Gauthier-Villars, M. ;
Labrune, P. ;
Bouyer, J. ;
Doz, F. ;
Kaminski, M. .
HUMAN REPRODUCTION, 2012, 27 (07) :2186-2192
[9]  
Franks LM, 1997, INTRO CELLULAR MOL B, P282
[10]   Increased risk for cancer among offspring of women with fertility problems [J].
Hargreave, Marie ;
Jensen, Allan ;
Deltour, Isabelle ;
Brinton, Louise A. ;
Andersen, Klaus K. ;
Kjaer, Susanne K. .
INTERNATIONAL JOURNAL OF CANCER, 2013, 133 (05) :1180-1186