Synthesis of Grafted Hydrogels as Mono-Divalent Cation Exchange for Drug Delivery

被引：21

作者：

El-Arnaouty, M. B. ^{[1
]}

Eid, M. ^{[1
]}

机构：

[1] Atom Author, Natl Ctr Radiat Res & Technol, Nasr City 11731, Cairo, Egypt

来源：

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2010年 / 49卷 / 02期

关键词：

Chlorphenamine maleate; Grafted hydrogels; Swelling; Thermal stability; THERMAL-DEGRADATION; DYNAMIC RELEASE; VITAMIN-B-12; RIBOFLAVIN; BEHAVIOR; PH;

D O I：

10.1080/03602550903284271

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

pH-sensitive acrylic acid grafted polyvinylalcohol (AAc-g-PVA) hydrogels has been prepared by gamma irradiation. The maximum grafting yield was at monomer concentration 50% and dose 50 kGy. The swelling, network parameters, thermogravimetric analysis, activation energy and scanning electron microscope of the grafted hydrogels were evaluated. Hydrogel demonstrate high swelling at pH 6.8. The deswelling of the swollen gel in Ni2+ and Cu2+ cations solution was explained on the basis of mono-divalent cation exchange. The release of antihistaminic chlorphenamine maleate hydrochloride (CPM) was faster in gastric fluid (SGF) of pH 1.1 than in intestinal fluid (SIF) of pH 6.8.

引用

页码：182 / 190

页数：9

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