Clinical aspects of hereditary hearing loss

被引：81
作者：
Kochhar, Amit [1 ]
Hildebrand, Michael S. [1 ]
Smith, Richard J. H. [1 ]
机构：
[1] Univ Iowa, Dept Otolaryngol Head & Neck Surg, Mol Otolaryngol Res Labs, Iowa City, IA 52242 USA
来源：
GENETICS IN MEDICINE | 2007年 / 9卷 / 07期
关键词：
hereditaty hearing loss; deafness; genetics; mutation; newborn hearing screening; congenital hearing loss; acquired hearing loss; syndromic hearing loss; nonsyndromic hearing loss; CONGENITAL CYTOMEGALOVIRUS-INFECTION; BRANCHIOOTORENAL BOR SYNDROME; VARIABLE EXPRESSIVITY; AUTOSOMAL-DOMINANT; ENDOTHELIN-3; GENE; MENTAL DEFICIENCY; SYNDROME TYPE-2; GJB2; MUTATIONS; USHER-SYNDROME; UNITED-STATES;
D O I：
10.1097/GIM.0b013e3180980bd0
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Hearing loss is an etiologically diverse condition with many disease-related complications and major clinical, social, and quality of life implications. As the rate of acquired hearing loss secondary to environmental causes decreases and improvements in the diagnosis of abnormalities occur, the significance of genetic factors that lead to deafness increases. Advancements in molecular biology have led to improved detection and earlier intervention in patients with hearing loss. Subsequently, earlier implementation of educational services and cochlear implant technology in patients with profound hearing loss now results in superior communication skills and enhanced language development. The aim of this review is to provide a comprehensive framework underlying the causes of hearing impairment and to detail the clinical management for patients with hereditary hearing loss.
引用
收藏
页码：393 / 408
页数：16
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