Triglyceride lipases and atherosclerosis

被引：39
作者：
Olivecrona, Gunilla [1 ]
Olivecrona, Thomas [1 ]
机构：
[1] Umea Univ, Dept Med Biosci, Physiol Chem Sect, SE-90187 Umea, Sweden
来源：
CURRENT OPINION IN LIPIDOLOGY | 2010年 / 21卷 / 05期
基金：
瑞典研究理事会;
关键词：
endothelial lipase; endothelial lipolysis site; hepatic lipase; lipoprotein lipase; ANGIOPOIETIN-LIKE PROTEINS; HEPARAN-SULFATE PROTEOGLYCANS; LIPOPROTEIN-LIPASE; ENDOTHELIAL LIPASE; FATTY-ACIDS; ADIPOSE-TISSUE; DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; HEPATIC LIPASE; DEFICIENT MICE;
D O I：
10.1097/MOL.0b013e32833ded83
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There are several ways by which derangement of the lipases may contribute to atherogenesis. Lipase actions are major determinants of plasma lipoprotein patterns. LPL activity must be modulated in relation to the physiological situation (feeding, fasting, exercise, etc.). Fatty acids and monoglycerides generated must be efficiently removed so that they do not endanger the integrity of the endothelium, cause lipotoxic reactions or both. In addition, the lipases may cause binding and endocytosis of lipoprotein particles in the artery wall.
引用
收藏
页码：409 / 415
页数：7
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