Innovation - New tools for functional mammalian cancer genetics

被引：86
作者：
Brummelkamp, TR
Bernards, R
机构：
[1] Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands
[2] Netherlands Canc Inst, Ctr Biomed Genet, NL-1066 CX Amsterdam, Netherlands
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 10期
关键词：
D O I：
10.1038/nrc1191
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Knowledge of the function of individual genes that encode components of cell-signalling pathways is crucial to our understanding of normal growth control and its deregulation in cancer, but we have functional information for only ∼15% of human genes at present. Several new technologies have recently become available to identify gene function in mammalian cells using high-throughput genetic screens. These new tools will make it possible to identify new and innovative classes of anticancer drugs, including those that show synthetic lethal interactions with cancer-specific mutations.
引用
收藏
页码：781 / 789
页数：9
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