Toward an artificial aldolase

被引：182

作者：

Font, Daniel ^{[1
,2
]}

Sayalero, Sonia ^{[1
]}

Bastero, Amaia ^{[1
]}

Jimeno, Ciril ^{[1
]}

Pericas, Miquel A. ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, E-43007 Tarragona, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 02期

关键词：

D O I：

10.1021/ol702901z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new functional polymer where proline is bonded to polystyrene through a 1,2,3-triazole linker depicts characteristics targeted for an artificial aldolase. In spite of the hydrophobicity of the polymer backbone, the resin swells in water with building of an aqueous microenvironment. This property, arising from the formation of a hydrogen-bond network connecting the proline and 1,2,3-triazole fragments, is translated into a very high catalytic activity and enantioselectivity toward direct aldol reactions in water.

引用

页码：337 / 340

页数：4

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