Chemerin is a protein ligand for the G protein-coupled receptor CMKLR1 and also binds to two atypical heptahelical receptors, CCRL2 and GPR1. Chemerin is a leukocyte attractant, adipokine, and antimicrobial protein. Although chemerin was initially identified as a highly expressed gene in healthy skin keratinocytes that was downregulated during psoriasis, the regulation of chemerin and its receptors in the skin by specific cytokines and microbial factors remains unexplored. Here we show that chemerin, CMKLR1, CCRL2 and GPR1 are expressed in human and mouse epidermis, suggesting that this tissue may be both a source and target for chemerin mediated effects. In human skin cultures, chemerin is significantly downregulated by IL-17 and IL-22, key cytokines implicated in psoriasis, whereas it is upregulated by acute phase cytokines oncostatin M and IL-1 beta. Moreover, we show that human keratinocytes in vitro and mouse skin in vivo respond to specific microbial signals to regulate expression levels of chemerin and its receptors. Furthermore, in a cutaneous infection model, chemerin is required for maximal bactericidal effects in vivo. Together, our findings reveal previously uncharacterized regulators of chemerin expression in skin and identify a physiologic role for chemerin in skin barrier defense against microbial pathogens.
机构:
Columbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Barnea, Gilad
;
Strapps, Walter
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Strapps, Walter
;
Herrada, Gilles
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Herrada, Gilles
;
Berman, Yemiliya
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Berman, Yemiliya
;
Ong, Jane
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Ong, Jane
;
Kloss, Brian
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Kloss, Brian
;
Axel, Richard
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Axel, Richard
;
Lee, Kevin J.
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USA
Univ Roma Tor Vergata, Dept Dermatol, Rome, ItalyRockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Chiricozzi, Andrea
;
Nograles, Kristine E.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Nograles, Kristine E.
;
Johnson-Huang, Leanne M.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Johnson-Huang, Leanne M.
;
Fuentes-Duculan, Judilyn
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Fuentes-Duculan, Judilyn
;
Cardinale, Irma
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Cardinale, Irma
;
Bonifacio, Kathleen M.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Bonifacio, Kathleen M.
;
Gulati, Nicholas
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Gulati, Nicholas
;
Mitsui, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Mitsui, Hiroshi
;
Guttman-Yassky, Emma
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USA
Mt Sinai Sch Med, Dept Dermatol, New York, NY USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Guttman-Yassky, Emma
;
Suarez-Farinas, Mayte
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Suarez-Farinas, Mayte
;
Krueger, James G.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
机构:
Columbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Barnea, Gilad
;
Strapps, Walter
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Strapps, Walter
;
Herrada, Gilles
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Herrada, Gilles
;
Berman, Yemiliya
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Berman, Yemiliya
;
Ong, Jane
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Ong, Jane
;
Kloss, Brian
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Kloss, Brian
;
Axel, Richard
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
Axel, Richard
;
Lee, Kevin J.
论文数: 0引用数: 0
h-index: 0
机构:
Sentigen Biosci, New York, NY 10032 USAColumbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Cellular Biophys, Howard Hughes Med Inst, New York, NY 10032 USA
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USA
Univ Roma Tor Vergata, Dept Dermatol, Rome, ItalyRockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Chiricozzi, Andrea
;
Nograles, Kristine E.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Nograles, Kristine E.
;
Johnson-Huang, Leanne M.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Johnson-Huang, Leanne M.
;
Fuentes-Duculan, Judilyn
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Fuentes-Duculan, Judilyn
;
Cardinale, Irma
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Cardinale, Irma
;
Bonifacio, Kathleen M.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Bonifacio, Kathleen M.
;
Gulati, Nicholas
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Gulati, Nicholas
;
Mitsui, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Mitsui, Hiroshi
;
Guttman-Yassky, Emma
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USA
Mt Sinai Sch Med, Dept Dermatol, New York, NY USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Guttman-Yassky, Emma
;
Suarez-Farinas, Mayte
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Suarez-Farinas, Mayte
;
Krueger, James G.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10021 USARockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA