Protein adsorption on topographically nanostructured titanium

被引:51
|
作者
Galli, C [1 ]
Coen, MC
Hauert, R
Katanaev, VL
Wymann, MP
Gröning, P
Schlapbach, L
机构
[1] Univ Fribourg, Dept Solid State Phys, CH-1700 Fribourg, Switzerland
[2] Univ Fribourg, Inst Biochem, CH-1700 Fribourg, Switzerland
[3] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA
[4] Swiss Fed Labs Mat Testing & Res, EMPA, CH-8600 Dubendorf, Switzerland
关键词
atomic force microscopy; surface structure; morphology; roughness; and topography; chemisorption; titanium oxide; biological molecules - proteins;
D O I
10.1016/S0039-6028(00)01054-2
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We study the protein adsorption on surfaces in order to investigate their predominant role in biocompatibility. Nanostructures are created by local anodic oxidation on titanium using the atomic force microscope. A remarkable specificity of the actin filament adsorption on the nanostructure height is noticed. F-actin is observed to have a low adsorption on nanostructures of a height of 4 nm and the adsorbed proteins appear to be randomly oriented. In contrast high protein adsorption is observed for structure height between 1 and 2 nm, moreover the filaments adsorb preferentially parallel to the nanostructured pattern. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:L180 / L184
页数:5
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