The effect of leptin on adrenal glands in rats with streptozotocin-induced diabetes - An experimental study

被引：0
作者：
Ergin, Kemal
Aktug, Hueseyin
Basaloglu, Hulki
Basaloglu, Hatice Kuebra
Yilmaz, Mahmut Ilker
Turgut, Mehmet
机构：
[1] Adnan Menderes Univ, Sch Med, Dept Histol & Embryol, Aydin, Turkey
[2] Adnan Menderes Univ, Sch Med, Dept Anat, Aydin, Turkey
[3] Adnan Menderes Univ, Sch Med, Dept Neurosurg, Aydin, Turkey
[4] Ege Univ, Sch Med, Dept Histol & Embryol, Izmir, Turkey
[5] Gulhane Mil Med Acad, Dept Nephrol, Ankara, Turkey
来源：
ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY | 2007年 / 29卷 / 05期
关键词：
adrenal gland; diabetes mellitus; leptin; streptozotocin;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
OBJECTIVE: To determine the cross-section area of adrenal medulla and the percentage of Ki-67 (a proliferation marker) of the adrenal gland in diabetic rats after leptin injection. STUDY DESIGN. Twenty-nine male Wistar rats were randomly divided into 3 groups: control (C) group (n = 9), diabetes mellitus (DM) group (n = 10) and leptin-injected diabetes mellitus (DM+L) group (n = 10). Experimental DM was induced by a single intraperitoneal dose of streptozolocin (40 mg/kg). After this, leptin (100,mu g/kg) was injected subcutaneously for a period of 2 weeks in the diabetic group. RESULTS: An atrophy of adrenal medulla in the DM group was observed, and this atrophy returned to normal morphology after injection of leptin. In addition, an increase in the Ki-67 percentage was demonstrated in the zona reticularis layers in the DM+L group. CONCLUSION: Our study indicated that leptin stimulates the sympathoadrenal system and the androgen pro-ducing adrenal cortex in DM rats.
引用
收藏
页码：291 / 295
页数：5
相关论文
共 28 条
[1]   Leptin is a metabolic signal to the reproductive system [J].
Barash, IA ;
Cheung, CC ;
Weigle, DS ;
Ren, HP ;
Kabigting, EB ;
Kuijper, JL ;
Clifton, DK ;
Steiner, RA .
ENDOCRINOLOGY, 1996, 137 (07) :3144-3147
[2]   Diabetes-induced neuroendocrine changes in rats: role of brain monoamines, insulin and leptin [J].
Barber, M ;
Kasturi, BS ;
Austin, ME ;
Patel, KP ;
MohanKumar, SMJ ;
MohanKumar, PS .
BRAIN RESEARCH, 2003, 964 (01) :128-135
[3]   Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland - Leptin inhibits cortisol release directly [J].
Bornstein, SR ;
Uhlmann, K ;
Haidan, A ;
EhrhartBornstein, M ;
Scherbaum, WA .
DIABETES, 1997, 46 (07) :1235-1238
[4]   Neuroendocrine regulation and actions of leptin [J].
Casanueva, FF ;
Dieguez, C .
FRONTIERS IN NEUROENDOCRINOLOGY, 1999, 20 (04) :317-363
[5]   Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: Effects of insulin treatment [J].
Chan, O ;
Chan, S ;
Inouye, K ;
Vranic, M ;
Matthews, SG .
ENDOCRINOLOGY, 2001, 142 (11) :4872-4879
[6]   Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: Potential clinical implications [J].
Charmandari, E ;
Weise, M ;
Bornstein, SR ;
Eisenhofer, G ;
Keil, MF ;
Chrousos, GP ;
Merke, DP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (05) :2114-2120
[7]   Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin [J].
Chehab, FE ;
Lim, ME ;
Lu, RH .
NATURE GENETICS, 1996, 12 (03) :318-320
[8]   DECREASED SYMPATHOCHROMAFFIN ACTIVITY IN IDDM [J].
CRYER, PE .
DIABETES, 1989, 38 (04) :405-409
[9]   EXPRESSION OF OB MESSENGER-RNA AND ITS ENCODED PROTEIN IN RODENTS - IMPACT OF NUTRITION AND OBESITY [J].
FREDERICH, RC ;
LOLLMANN, B ;
HAMANN, A ;
NAPOLITANOROSEN, A ;
KAHN, BB ;
LOWELL, BB ;
FLIER, JS .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (03) :1658-1663
[10]   Expression of Ob receptor in normal human adrenals: Differential regulation of adrenocortical and adrenomedullary function by leptin [J].
Glasow, A ;
Haidan, A ;
Hilbers, U ;
Breidert, M ;
Gillespie, J ;
Scherbaum, WA ;
Chrousos, GP ;
Bornstein, SR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (12) :4459-4466
123