New Bis(dihydropyridine-3,5-dicarbonitrile) Derivatives: Green Synthesis and Cytotoxic Activity Evaluation

被引：45

作者：

Abdelmoniem, Amr M. ^{[1
]}

Salaheldin, Taher A. ^{[2
]}

Abdelhamid, Ismail A. ^{[1
]}

Elwahy, Ahmed H. M. ^{[1
]}

机构：

[1] Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt

[2] Agr Res Ctr, Nanotechnol & Adv Mat Cent Lab, Cairo 12631, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 05期

关键词：

SUBSTITUTED MACROCYCLIC LIGANDS; HETEROCYCLIC SYNTHESIS; ANTITUMOR AGENTS; PRECURSORS; INHIBITORS; SUBUNITS; PYRIDINE; ANALOGS;

D O I：

10.1002/jhet.2867

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of bis(dihydropyridine-3,5-dicarbonitrile) by a three-component reaction of one equivalent of bis-cyanoacetamides with two equivalents of both arylaldehydes and malononitrile in ethanol-containing piperidine is reported. Bis-cyanopyridones could also be obtained by the condensation of bis-cyanoacetamides with substituted arylidenemalononitriles in the presence of piperidine, chitosan, or montmorillonite as basic catalysts. The cytotoxicity of the synthesized products against the heterogeneous human epithelial colorectal adenocarcinoma cell line (Caco-2) was assessed by WST-1 assay with concentration dependent cellular growth inhibitory effect especially for compounds 5l, 5h, and 5d. The dose response curves indicate that IC50 were 87 +/- 3.11g/mL, 104 +/- 4.78g/mL, and 108 +/- 5.12g/mL, respectively.

引用

页码：2670 / 2677

页数：8

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