Long-range carbon-proton coupling constants for stereochemical assignment of acyclic structures in natural products: Configuration of the C5-C9 portion of maitotoxin

被引：49

作者：

Matsumori, N

Nonomura, T

Sasaki, M

Murata, M

Tachibana, K

Satake, M

Yasumoto, T

机构：

[1] UNIV TOKYO,FAC SCI,DEPT CHEM,BUNKYO KU,TOKYO 113,JAPAN

[2] TOHOKU UNIV,FAC AGR,AOBA KU,SENDAI,MIYAGI 981,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 08期

关键词：

D O I：

10.1016/0040-4039(95)02413-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Long-range carbon-proton coupling constants ((2,3)J(CH)) were measured for maitotoxin (MTX), one of the largest natural non-biopolymers, by hetero-half filter experiments and phase-sensitive HMBC with use of 9 mg of a 4% C-13-enriched sample. The necessary coupling constants within the terminal acyclic portions of MTX, where NOE analysis was not successful owing to the presumed coexistence of multiple conformers, were thus obtained for the resultant elucidation of relative configurations for the acyclic stereogenic centers to be 5R*, 7R*, 8R*, and 9S*.

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页码：1269 / 1272

页数：4

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