Sesquiterpenes from Santolina chamaecyparissus subsp. squarrosa

Four new sesquiterpenes, (E)-6 beta-acetoxy-7 alpha K-germacra-4,10(14)-diene-1 alpha,2 beta-diol (1), (4E,9Z)-6 beta-acetoxy-7 alpha H-germacra-4,9-diene-1 alpha,2 beta-diol (2), (E)-6 beta-acetoxy-7 alpha H-germacra-1(10),4-diene-2 beta-ol (3) and 6-beta-acetoxy-5 beta H,7 alpha H,10 beta Me-eudesm-4(15)-ene-1 alpha,2 beta-dol (4), were identified in the ether extract from the aerial parts of Santolina chamaecyparissus subsp. squarrosa. Their structures and preferred conformation in solution were determined by spectroscopic methods and molecular mechanics calculations. (C) 1998 Elsevier Science Ltd. All rights reserved.