Electrospinning of Photosensitizer-loaded PLLA Nanofabrics for Anticancer Therapy

Photodynamic therapy (PDT) is a promising new treatment for cancer that has been recently accepted in the clinic. PDT is based on the administration of tumour-localizing photosensitizers (PSs), followed by the exposure of the neoplastic area to light absorbed by the PS. In this paper, a novel anticancer nanofabric membrance containing purpurin- 18(0. 1%) was successfully prepared. The thickness of membrane was 0.03 mm, and the average fiber diameter was 400 nm by scanning electron micrograph (SEM). It was indicated that PS purpurin-18 possessed excellent compatibility with PLLA from FT-IR spectrum. The physical properties of fabric membrane also were characterized by Differential Scanning Calorimetry (DSC) and X-ray diffraction (XRD).