Facile Benzo-Ring Construction via Palladium-Catalyzed Functionalization of Unactivated sp3 C-H Bonds under Mild Reaction Conditions

被引：137

作者：

Feng, Yiqing ^{[1
]}

Wang, Yuji ^{[1
]}

Landgraf, Bradley ^{[1
]}

Liu, Shi ^{[1
]}

Chen, Gong ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 15期

关键词：

ORGANOPALLADIUM(IV) CHEMISTRY; ORGANOMETALLIC CHEMISTRY; COUPLING REACTIONS; ORGANIC-MOLECULES; ROOM-TEMPERATURE; DIRECT ARYLATION; DIRECTING GROUP; AMINO-ACIDS; ACTIVATION; MECHANISM;

D O I：

10.1021/ol101220x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthetic method for the annulation of benzo-rings by the intramolecular coupling of an aryl Iodide and a methylene C H bond is described. The palladium-catalyzed C-H functionalization Is directed by an aminoquinoline carboxamide group, which can be easily installed and removed. High yields and broad substrate scope were achieved. An additive of ortho-phenyl benzoic acid, identified from a systematic screening, functions as a critical ligand for the catalytic process under mild condition, even at near room temperature.

引用

页码：3414 / 3417

页数：4

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