Screening antimutagenic and antiproliferative properties of extracts isolated from Jackfruit pulp (Artocarpus heterophyllus Lam)

被引：25

作者：

Ruiz-Montanez, G. ^{[1
]}

Burgos-Hernandez, A. ^{[2
]}

Calderon-Santoyo, M. ^{[1
]}

Lopez-Saiz, C. M. ^{[2
]}

Velazquez-Contreras, C. A. ^{[3
]}

Navarro-Ocana, A. ^{[4
]}

Ragazzo-Sanchez, J. A. ^{[1
]}

机构：

[1] Inst Tecnol Tepic, Lab Integral Invest Alimentos, Tepic 63175, Nayarit, Mexico

[2] Univ Sonora, Dept Invest & Posgrad Alimentos, Hermosillo 8300, Sonora, Mexico

[3] Univ Sonora, Dept Ciencias Quim Biol, Hermosillo 1658, Sonora, Mexico

[4] Univ Nacl Autonoma Mexico, Fac Quim, Coyoacan 04510, DF, Mexico

来源：

FOOD CHEMISTRY | 2015年 / 175卷

关键词：

Jackfruit pulp; Antiproliferative; Antimutagenic; Antioxidant; RP-HPLC; Chemoprotective properties; CANCER CHEMOPREVENTION; ANTIOXIDANT CAPACITY; FRUIT; DIET; PREVENTION; ASSAY;

D O I：

10.1016/j.foodchem.2014.11.122

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The present focused on the study of the antimutagenic and antiproliferative potential of pulp Jackfruit (Artocarpus heterophyllus Lam) extract, using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line M12.C3.F6 (murine B-cell lymphoma), respectively. Jack-fruit pulp extract was sequentially fractionated by chromatography (RP-HPLC) and each fraction was tested for antimutagenic and antiproliferative activities. The organic extracts obtained from Jackfruit pulp reduced the number of revertants caused by aflatoxin B1 (AFB1) and proliferation of cells M12.C3.F6; a dose-response relationship was showed. Sequential RP-HPLC fractionation of the active extracts produced both antimutagenic and/or antiproliferative fractions. These results suggested that the Jackfruit contained compounds with chemoprotective properties to reduce the mutagenicity of AFB1, also proliferation of a cancer cell line. (c) 2014 Elsevier Ltd. All rights reserved.

引用

页码：409 / 416

页数：8

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