Celiac disease in adult patients with type 1 diabetes mellitus in Tunisia

被引:25
|
作者
Bouguerra, R
Ben Salem, L
Chaabouni, H
Laadhar, L
Essais, O
Zitouni, M
Haouet, S
Ben Slama, C
Ben Ammar, A
Zouari, B
Makni, S
机构
[1] Natl Inst Nutr, Tunis 1007, Tunisia
[2] Hop Rabta, Unite Rech Malad Coeliaque, Rabt, Morocco
[3] Fac Med Tunis, Tunis, Tunisia
关键词
celiac disease; adult type1 diabetes mellitus; prevalence; screening;
D O I
10.1016/S1262-3636(07)70171-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Type1 diabetes mellitus may be associated with celiac disease. The prevalence of celiac disease as determined by screening among adult patients with type 1 diabetes is high with rates of 1.0-7.8% in Europe and U.S.A. The aims of the study are to determine the prevalence of celiac disease in adults with type 1 diabetes in Tunisia. Methods: 348 consecutive adult patients with type1 diabetes were investigated prospectively and screened for celiac disease. The mean age was 28.45 +/- 10.74 years old. There were 176 females and 172 males. For the screening of celiac disease, we used immunoglobulin A (IgA) anti-endomysium (EMA) antibodies determined by an indirect immunofluorescence method. Anti-transglutaminase (tTG) antibodies were determined by an ELISA method. Those patients with positive results for anti EMA and or tTG were proposed for duodenal biopsy. Results: 14 patients were positive for anti EMA and had high or a weak positive level of tTG antibodies. One patient from this group was already known to have celiac disease. Only 8 patients consented to biopsy and morphological changes were consistent with celiac disease in all cases. Prevalence of biopsy-proven celiac disease was 2.3% (95% CI = 1.0-4.5%). Conclusion: The present study confirms that celiac disease of adults is prevalent in type 1 diabetic patients in Tunisia. Serological screening for celiac disease in type 1 diabetes is important because many patients are asymptomatic and most are detected by the screening.
引用
收藏
页码:83 / 86
页数:4
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