Tracing genetic change over time using nuclear SNPs in ancient and modern cattle

被引：67

作者：

Svensson, E. M.

Anderung, C.

Baubliene, J.

Persson, P.

Malmstrom, H.

Smith, C.

Vretemark, M.

Daugnora, L.

Gotherstrom, A.

机构：

[1] Uppsala Univ, Evolutionary Biol Ctr, S-75236 Uppsala, Sweden

[2] Lithuanian Vet Acad, LT-47181 Kaunas, Lithuania

[3] Gothenburg Univ, Dept Archaeol, S-40530 Gothenburg, Sweden

[4] Univ Durham, Dept Archaeol, Durham DH1 3LE, England

[5] Max Planck Inst Evolutionary Antropol, Dept Human Evolut, D-04103 Leipzig, Germany

[6] Vastergotlands Museum, Skara, Sweden

来源：

ANIMAL GENETICS | 2007年 / 38卷 / 04期

关键词：

ancient DNA; Bos taurus; genetic diversity; pyrosequencing; selection; single nucleotide polymorphism;

D O I：

10.1111/j.1365-2052.2007.01620.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Ancient DNA has the potential of adding the dimension of time to genetic studies. With a suitable sample set it should be possible to follow genetic changes over time as they occur. To date, only a limited number of ancient DNA studies that cover a large time span have been published, and all of these studies have used mitochondrial DNA. Here, we explore SNP typing as a way to access ancient coding nuclear genes. By targeting fragments of minimal size, we typed three polymorphic sites in 111 ancient cattle remains spanning some 4000 years. We showed that there has been a decrease in heterozygosity over time, especially since the late Middle Ages. We conclude that SNPs can be used to generate a time series for nuclear markers from ancient material, and thereby to study selection on genes over time.

引用

页码：378 / 383

页数：6

共 34 条

[1] Genetic dissection of phenotypic diversity in farm animals
Andersson, L
[J]. NATURE REVIEWS GENETICS, 2001, 2 (02) : 130 - 138
[2] Prehistoric contacts over the Straits of Gibraltar indicated by genetic analysis of Iberian Bronze Age cattle
Anderung, C
Bouwman, A
Persson, P
Carretero, JM
Ortega, AI
Elburg, R
Smith, C
Arsuaga, JL
Ellegren, H
Götherström, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (24) : 8431 - 8435
[3] The leptin C73T missense mutation is not associated with marbling and fatness traits in a large gene mapping experiment in Australian cattle
Barendse, W
Bunch, RJ
Harrison, BE
[J]. ANIMAL GENETICS, 2005, 36 (01) : 86 - 88
[4] BERAUDCOLOMB E, 1995, AM J HUM GENET, V57, P1267
[5] Bouwman AS, 2002, ANCIENT BIOMOLECULES, V4, P173, DOI DOI 10.1080/1358612021000028470
[6] BROCK JC, 1999, NATURAL HIST DOMESTI
[7] ANCIENT DNA AND THE ARCHAEOLOGIST
BROWN, TA
BROWN, KA
[J]. ANTIQUITY, 1992, 66 (250) : 10 - 23
[8] Hot topic:: An association between a leptin single nucleotide polymorphism and milk and protein yield
Buchanan, FC
Van Kessel, AG
Waldner, C
Christensen, DA
Laarveld, B
Schmutz, SM
[J]. JOURNAL OF DAIRY SCIENCE, 2003, 86 (10) : 3164 - 3166
[9] Buchanan FC, 2002, GENET SEL EVOL, V34, P105, DOI [10.1051/gse:2001006, 10.1186/1297-9686-34-1-105]
[10] Extreme reversed sexual size dimorphism in the extinct New Zealand moa Dinornis
Bunce, M
Worthy, TH
Ford, T
Hoppitt, W
Willerslev, E
Drummond, A
Cooper, A
[J]. NATURE, 2003, 425 (6954) : 172 - 175

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