COVID-19 & differential effects in twins: Insights from Placenta Pathology

被引：4

作者：

Moriarty, Kristen ^{[1
]}

Yu, Mingfu ^{[2
]}

Hussain, Naveed ^{[3
]}

Zgutka, Kinga ^{[3
]}

Sanders, M. Melinda ^{[2
]}

Harigopal, Malini ^{[4
]}

Wang, Jianhui ^{[4
]}

Wang, Xi ^{[4
]}

Hui, Pei ^{[4
]}

Liu, Chen ^{[4
]}

Sink, David ^{[3
]}

Shields, Andrea ^{[1
]}

机构：

[1] Univ Connecticut, Dept Obstet & Gynecol, Storrs, CT USA

[2] Univ Connecticut, Dept Pathol, Storrs, CT USA

[3] Connecticut Childrens Med Ctr, Dept Pediat, Hartford, CT USA

[4] Yale Univ, Dept Pathol, New Haven, CT 06520 USA

来源：

PLACENTA | 2022年 / 124卷

关键词：

SARS-COV-2; INFECTION; PREGNANCY; ACE2;

D O I：

10.1016/j.placenta.2022.05.014

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Introduction: COVID-19 has been associated with several adverse pregnancy outcomes, including perinatal loss. Differential effects of COVID-19 in a twin pregnancy may provide unique insights into virus-placental interactions. We present a case of perinatal loss of a female fetus with survival of the male co-twin in a pregnancy complicated by COVID-19 and premature delivery. Methods: Viral detection methods recommended by the NICHD task force were used to identify SARS-CoV-2 and its viral receptors in the placentas and fetal tissue (Antoun et al., 2020) [1] Results: Compared with the surviving twin, we found a more severe intervillous necrosis and a relatively low detection of ACE2 membranous expression in the syncytiotrophoblasts of the female twin that succumbed. Discussion: The interactions of SARS-CoV-2 and ACE2 at the maternal fetal interface within the placenta may play a significant role in perinatal loss, and the effects of fetal sex and gestational age at time of infection need to be explored further.

引用

页码：62 / 66

页数：5

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