Efficient Synthesis and Evaluation of Antitumor Activities of Novel Functionalized 1,8-Naphthyridine Derivatives

被引：48
作者：
Fu, Lei [1 ]
Feng, Xian [1 ]
Wang, Jian-Jun [1 ]
Xun, Zhan [1 ]
Hu, Jun-Die [1 ]
Zhang, Juan-Juan [1 ]
Zhao, Yan-Wei [1 ]
Huang, Zhi-Bin [1 ]
Shi, Da-Quig [1 ]
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
来源：
ACS COMBINATORIAL SCIENCE | 2015年 / 17卷 / 01期
关键词：
1,8-naphthyridine; chromeno[2,3-b]quinoline; cascade reaction; antitumor activity; ONE-POT SYNTHESIS; HETEROCYCLIC KETENE AMINALS; BIOLOGICAL EVALUATION; 3-COMPONENT REACTION; DOMINO REACTIONS; CASCADE REACTION; CONSTRUCTION; FLUORESCENT; FLUOROQUINOLONES; ANTICANCER;
D O I：
10.1021/co500120b
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient synthesis of novel functionalized 1,8-naphthyridine and chromeno[2,3-b]quinoline derivatives via cascade reaction of 2-chloroquinoline-3-carbaldehyde and enaminones or cyclic 1,3-dicarbonyl compounds was developed. All of the 1,8-naphthyridine derivatives synthesized were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have high activities.
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页码：24 / 31
页数：8
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