Efficient Synthesis and Evaluation of Antitumor Activities of Novel Functionalized 1,8-Naphthyridine Derivatives

被引：48

作者：

Fu, Lei ^{[1
]}

Feng, Xian ^{[1
]}

Wang, Jian-Jun ^{[1
]}

Xun, Zhan ^{[1
]}

Hu, Jun-Die ^{[1
]}

Zhang, Juan-Juan ^{[1
]}

Zhao, Yan-Wei ^{[1
]}

Huang, Zhi-Bin ^{[1
]}

Shi, Da-Quig ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

ACS COMBINATORIAL SCIENCE | 2015年 / 17卷 / 01期

关键词：

1,8-naphthyridine; chromeno[2,3-b]quinoline; cascade reaction; antitumor activity; ONE-POT SYNTHESIS; HETEROCYCLIC KETENE AMINALS; BIOLOGICAL EVALUATION; 3-COMPONENT REACTION; DOMINO REACTIONS; CASCADE REACTION; CONSTRUCTION; FLUORESCENT; FLUOROQUINOLONES; ANTICANCER;

D O I：

10.1021/co500120b

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient synthesis of novel functionalized 1,8-naphthyridine and chromeno[2,3-b]quinoline derivatives via cascade reaction of 2-chloroquinoline-3-carbaldehyde and enaminones or cyclic 1,3-dicarbonyl compounds was developed. All of the 1,8-naphthyridine derivatives synthesized were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have high activities.

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页码：24 / 31

页数：8

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