Increased plasma levels of epithelial neutrophil-activating peptide 78/CXCL5 during the remission of Neuromyelitis optica

被引:19
作者
Yang, Tao [1 ]
Wang, Su [2 ]
Zheng, Qi [3 ,4 ]
Wang, Lei [4 ]
Li, Qian [1 ]
Wei, Mingyan [1 ]
Du, Zongpan [1 ]
Fan, Yongping [1 ]
机构
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Tradit Chinese Med, Beijing 100050, Peoples R China
[2] Hiser Med Ctr Qingdao, Dept Oncol, Qingdao 266034, Peoples R China
[3] China Acad Chinese Med Sci, Guang An Men Hosp, Dept Oncol, Beijing 100053, Peoples R China
[4] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100050, Peoples R China
基金
中国国家自然科学基金;
关键词
Neuromyelitis optica; Epithelial neutrophil-activating peptide 78; Interleukin; 1; beta; Tumor necrosis factor alpha; IN-VIVO; MULTIPLE-SCLEROSIS; OLIGODENDROCYTE PRECURSORS; CEREBROSPINAL-FLUID; IMMUNOGLOBULIN-G; SPINAL-CORD; STEM-CELLS; TNF-ALPHA; CXCL5; CHEMOKINES;
D O I
10.1186/s12883-016-0622-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: In neuromyelitis optica (NMO), one of the underlying pathogenic mechanisms is the formation of antigen-antibody complexes which can trigger an inflammatory response by inducing the infiltration of neutrophils in lesions. Epithelial neutrophil-activating peptide 78 (ENA 78), known as Chemokine (C-X-C motif) ligand 5 (CXCL5), belongs to the ELR-CXCL family. It recruits and activates neutrophils. The aim of this study was to evaluate ENA 78, IL-1 beta and TNF-alpha plasma levels in multiple sclerosis (MS) and neuromyelitis optica (NMO) patients. Methods: ENA 78, IL-1 beta and TNF-alpha plasma levels were detected in 20 healthy controls (HC), 25 MS and 25 NMO patients using MILLIPLEX (R) map Human High Sensitivity Cytokine/Chemokine Panels. Results: Plasma levels of ENA 78 were significantly higher in NMO patients than in HC (P < 0.001) and MS patients (P < 0.05). The NMO patients showed higher plasma levels of IL-1 beta compared with HC (P < 0.01). Further, increased plasma levels of TNF-alpha were found in the MS (P < 0.05) and NMO patients (P < 0.001). In addition, NMO patients had higher Expanded Disability Status Scale (EDSS) scores compared with MS patients (P < 0.05). EDSS scores were correlated with plasma levels of ENA 78 in NMO patients (P < 0.05). There were no significant correlations between EDSS scores and plasma levels of ENA 78 in MS patients (P > 0.05). Conclusions: The overproduction of pro-inflammatory cytokines such as IL-1 beta and TNF-alpha during the remission of NMO activates ENA 78, which in turn leads to neutrophil infiltration in lesions. ENA 78 plasma levels were correlated with EDSS scores in NMO patients. Elevated secretion of ENA 78 may be a critical step in neutrophil recruitment during the remission of NMO.
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页数:6
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