Synthesis structure and stability of amino functionalized PEGylated silica nanoparticles

被引：32

作者：

Branda, F. ^{[1
]}

Silvestri, B. ^{[1
]}

Luciani, G. ^{[1
]}

Costantini, A. ^{[1
]}

Tescione, F. ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Mat & Engn Prod, I-80125 Naples, Italy

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2010年 / 367卷 / 1-3期

关键词：

PEG-SiO2; nanoparticles; Stober Method; DRUG-DELIVERY; ENCAPSULATION; BIOMOLECULES; PARTICLES;

D O I：

10.1016/j.colsurfa.2010.05.036

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Amino functionalized PEGylated silica nanoparticles were prepared by one pot-procedure, based on ammonia catalysed hydrolysis and polycondensation of Tetraethoxysilane (TEOS) and 3-Aminopropyltriethoxysylane (APTS), in alcohol medium (ethanol) (Sather method), containing PEG 5000 monomethyl ether. Particles size was studied using Transmission Electron Spectroscopy (TEM). PEGylation and amino functionalization was investigated through FT-IR and Thermogravimetric analysis (TG). The structure of nanoparticles consists of nanosilica (a few nanometers in size) dispersed into a PEG matrix, produced by entanglement of PEG chains. The stability of the water colloidal suspension depends on the PEG/silica mass ratio, that changes with PEG concentration in the reaction batch. By properly selecting the PEG concentration, nanoparticles smaller than 150 nm were obtained, stable towards aggregation in water media up to 6 months. The observed need of an optimal PEG/silica mass ratio for long-term stability can be explained on the basis of particles structure and assuming that both steric and electrostatic effect concur to stabilisation. (C) 2010 Elsevier BM. All rights reserved.

引用

页码：12 / 16

页数：5

共 40 条

[1]

Alcantar NA, 2000, J BIOMED MATER RES, V51, P343, DOI 10.1002/1097-4636(20000905)51:3<343::AID-JBM7>3.0.CO

[2]

2-D

[3] PREPARATION OF MONODISPERSE SILICA PARTICLES - CONTROL OF SIZE AND MASS FRACTION [J].

BOGUSH, GH ;

TRACY, MA ;

ZUKOSKI, CF .

JOURNAL OF NON-CRYSTALLINE SOLIDS, 1988, 104 (01) :95-106

[4] UNIFORM SILICA PARTICLE-PRECIPITATION - AN AGGREGATIVE GROWTH-MODEL [J].

BOGUSH, GH ;

ZUKOSKI, CF .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1991, 142 (01) :19-34

[5]

BOGUSH GH, 1991, J COLLOID INTERF SCI, V142, P18

[6] The effect of mixing alkoxides on the Stober particles size [J].

Branda, F. ;

Silvestri, B. ;

Luciani, G. ;

Costantini, A. .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2007, 299 (1-3) :252-255

[7]

Brinker C. J., 2013, SOL GEL SCI PHYS CHE, DOI [DOI 10.1016/B978-0-08-057103-4.50001-5, 10.1016/C2009-0-22386-5]

[8] Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases [J].

Feng, SS ;

Chien, S .

CHEMICAL ENGINEERING SCIENCE, 2003, 58 (18) :4087-4114

[9]

FLETT MS, 1963, CHARACTERISTIC FREQU

[10] A new interatomic potential for nanoscale silica [J].

Flikkema, E ;

Bromley, ST .

CHEMICAL PHYSICS LETTERS, 2003, 378 (5-6) :622-629

← 1 2 3 4 →