Highly Enantioselective Cobalt-Catalyzed Hydrosilylation of Alkenes

被引：176

作者：

Cheng, Biao ^{[1
]}

Lu, Peng ^{[1
]}

Zhang, Heyi ^{[1
]}

Cheng, Xinpeng ^{[1
]}

Lu, Zhan ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310058, Zhejiang, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 28期

关键词：

CROSS-COUPLING REACTIONS; SILICON BOND FORMATION; ASYMMETRIC HYDROSILYLATION; ORGANIC-SYNTHESIS; INTRAMOLECULAR HYDROSILATION; MARKOVNIKOV HYDROSILYLATION; COMPLEXES; SILANES; OLEFINS; LIGANDS;

D O I：

10.1021/jacs.7b04137

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cobalt-catalyzed highly Markovnikov-type and enantioselective hydrosilylation of alkenes is developed for the efficient synthesis of valuable chiral dihydrosilanes. This protocol is operationally simple and atom-economy, and using relatively simple and readily available starting materials. The reaction is suitable for both aryl and aliphatic alkenes with excellent functional group tolerability. The reaction could be easily carried out in a gram-scale. The TOF and TON is up to 1800 and 860, respectively.

引用

页码：9439 / 9442

页数：4

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