Respiratory medicine - genetic base for allergy and asthma

被引：13

作者：

Binia, Aristea ^{[2
,3
]}

Kabesch, Michael ^{[1
,2
]}

机构：

[1] KUNO Childrens Hosp Regensburg, Dept Pediat Pneumol & Allergy, KUNO Childrens Univ Clin, DE-93049 Regensburg, Germany

[2] Hannover Med Sch, Dept Pediat Pneumol Allergy & Neonatol, D-3000 Hannover, Germany

[3] Nestle Res Ctr, Bioanalyt Sci Dept, CH-1000 Lausanne, Switzerland

来源：

SWISS MEDICAL WEEKLY | 2012年 / 142卷

关键词：

genetics; asthma; allergy; respiratory medicine; GENOME-WIDE ASSOCIATION; HUMAN BETA(2)-ADRENERGIC RECEPTOR; ACTING BETA-AGONISTS; INHALED CORTICOSTEROIDS; SUSCEPTIBILITY LOCI; FOLLOW-UP; FILAGGRIN MUTATIONS; PULMONARY-FUNCTION; ATOPIC-DERMATITIS; SEQUENCE VARIANTS;

D O I：

10.4414/smw.2012.13612

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Allergy and asthma are complex diseases influenced by many genes and molecular mechanisms. Recently a number of genome-wide association studies (GWAS) have investigated asthma-and allergy-related phenotypes. Results suggest the existence of sub phenotypes of asthma and document a need to better define the disease. Genetics may also help to identify groups of patients susceptible for specific forms of treatment and those at risk for adverse effects of therapy. Thus, genetics may represent a key tool to achieve individualised medicine in asthma and allergy in the future.

引用

页数：11

共 111 条

[1] Epigenetics and airways disease [J].

Adcock, IM ;

Ford, P ;

Ito, K ;

Barnes, PJ .

RESPIRATORY RESEARCH, 2006, 7 (1)

[2] Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population [J].

Andiappan, Anand Kumar ;

Wang, De Yun ;

Anantharaman, Ramani ;

Parate, Pallavi Nilkanth ;

Suri, Bani Kaur ;

Low, Hui Qi ;

Li, Yi ;

Zhao, Wanting ;

Castagnoli, Paola ;

Liu, Jianjun ;

Chew, Fook Tim .

PLOS ONE, 2011, 6 (05)

[3]

Artigas MS, 2011, NAT GENET 0527

[4] Efficacy and safety of inhaled corticosteroids - New developments [J].

Barnes, PJ ;

Pedersen, S ;

Busse, WW .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (03) :S1-S53

[5] Costs of asthma in the United States: 2002-2007 [J].

Barnett, Sarah Beth L. ;

Nurmagambetov, Tursynbek A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (01) :145-152

[6] Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes [J].

Barrett, Jeffrey C. ;

Clayton, David G. ;

Concannon, Patrick ;

Akolkar, Beena ;

Cooper, Jason D. ;

Erlich, Henry A. ;

Julier, Cecile ;

Morahan, Grant ;

Nerup, Jorn ;

Nierras, Concepcion ;

Plagnol, Vincent ;

Pociot, Flemming ;

Schuilenburg, Helen ;

Smyth, Deborah J. ;

Stevens, Helen ;

Todd, John A. ;

Walker, Neil M. ;

Rich, Stephen S. .

NATURE GENETICS, 2009, 41 (06) :703-707

[7] Adrenergic β2-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol [J].

Basu, Kaninika ;

Palmer, Colin N. A. ;

Tavendale, Roger ;

Lipworth, Brian J. ;

Mukhopadhyay, Somnath .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (06) :1188-1194

[8] IDENTIFICATION OF LYMPHOCYTES-T, MACROPHAGES, AND ACTIVATED EOSINOPHILS IN THE BRONCHIAL-MUCOSA IN INTRINSIC ASTHMA - RELATIONSHIP TO SYMPTOMS AND BRONCHIAL RESPONSIVENESS [J].

BENTLEY, AM ;

MENZ, G ;

STORZ, C ;

ROBINSON, DS ;

BRADLEY, B ;

JEFFERY, PK ;

DURHAM, SR ;

KAY, AB .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (02) :500-506

[9] Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma [J].

Berry, Mike ;

Morgan, Angela ;

Shaw, Dominick E. ;

Parker, Deborah ;

Green, Ruth ;

Brightling, Christopher ;

Bradding, Peter ;

Wardlaw, Andrew J. ;

Pavord, Ian D. .

THORAX, 2007, 62 (12) :1043-1049

[10] Human asthma phenotypes: from the clinic, to cytokines, and back again [J].

Bhakta, Nirav R. ;

Woodruff, Prescott G. .

IMMUNOLOGICAL REVIEWS, 2011, 242 :220-232

← 1 2 3 4 5 6 7 8 9 10 →