Objective: This study aimed to investigate the effects of personalized nursing on the hearing recovery of patients with sudden hearing loss (SHL) and the factors affecting their hearing recovery. Methods: We conducted a retrospective analysis of 92 patients with SHL admitted to our hospital and divided them into the good prognosis group (60 cases) and the poor prognosis group (32 cases) according to the prognosis, and we also divided them into the control group (those receiving routine nursing, 47 cases) and the observation group (those receiving the personalized nursing, 45 cases) according to the nursing methods. Univariate and multivariate logistic regression analyses were used to identify the factors affecting the hearing recovery. The hearing ability, the negative emotions, the stress response scores, and the patients' sleep quality were assessed before and after the nursing. Results: The univariate analysis showed that the hearing recovery in the patients with SHL was related to age, BMI, income, the number of affected ears, the degree of hearing loss, hypertension, diabetes, hyperlipidemia, and dizziness (P<0.05). The multivariate logistic regression analysis identified age, two affected ears, the degree of hearing loss, comorbid diabetes, and dizziness as independent risk factors affecting the hearing recovery in SHL patients (all P<0.001). After the nursing, compared with the patients from the control group, the patients from the observation group showed a superior hearing ability (P<0.05), lower scores on the Self-rating Anxiety Scale (SAS) and the Self-rating Depression Scale (SDS) (P<0.01), and lower scores on the Stanford Acute Stress Reaction Questionnaire (SASRQ) and the Pittsburgh Sleep Quality Index (PSQI) (all P<0.001). Conclusion: The independent risk factors affecting the hearing recovery in the SHL patients included age, the number of affected ears, the degree of hearing loss, diabetes, and dizziness. Systematic and comprehensive personalized nursing is effective at improving the hearing ability of SHL patients, enlightening new directions for clinical nursing.