Meiotic Origins of Maternal Age-Related Aneuploidy

被引：147
作者：
Chiang, Teresa [1 ]
Schultz, Richard M. [1 ]
Lampson, Michael A. [1 ]
机构：
[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
来源：
BIOLOGY OF REPRODUCTION | 2012年 / 86卷 / 01期
基金：
美国国家卫生研究院;
关键词：
aging; aneuploidy; female infertility; meiosis; oocyte; SPINDLE ASSEMBLY CHECKPOINT; REDUCTIONAL CHROMOSOME SEGREGATION; IN-VITRO FERTILIZATION; MOUSE MEIOSIS I; DOWN-SYNDROME; HUMAN OOCYTES; SISTER CHROMATIDS; DNA-REPLICATION; X-CHROMOSOME; FEMALE MICE;
D O I：
10.1095/biolreprod.111.094367
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Chromosome segregation errors in female meiosis lead to aneuploidy in the resulting egg and embryo, making them one of the leading genetic causes of spontaneous abortions and developmental disabilities in humans. It is known that aneuploidy of meiotic origin increases dramatically as women age, and current evidence suggests that most errors occur in meiosis I. Several hypotheses regarding the cause of maternal age-related aneuploidy have been proposed, including recombination errors in early meiosis, a defective spindle assembly checkpoint in meiosis I, and deterioration of sister chromatid cohesion with age. This review discusses findings in each area, and focuses especially on recent studies suggesting that deterioration of cohesion with increasing maternal age is a leading cause of age-related aneuploidy.
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页数：7
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